A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorDepartment of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, 68163 Mannheim, Germany;
dc.contributorInstitute of Molecular Systems Biology, Eidgenössische Technische Hochschule (ETH) Zürich, 8093 Zürich, Switzerland;
dc.contributorDepartment of Biology, Technical University Darmstadt, 64287 Darmstadt, Germany.
dc.contributorDepartment of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, 68163 Mannheim, Germany; m.mack@hs-mannheim.de.
dc.creatorPedrolli, Danielle Biscaro [UNESP]
dc.creatorKühm, Christian
dc.creatorSévin, Daniel C.
dc.creatorVockenhuber, Michael P.
dc.creatorSauer, Uwe
dc.creatorSuess, Beatrix
dc.creatorMack, Matthias
dc.date2015-12-07T15:39:40Z
dc.date2015-12-07T15:39:40Z
dc.date2015-10-22
dc.date.accessioned2023-09-12T07:38:54Z
dc.date.available2023-09-12T07:38:54Z
dc.identifierhttp://dx.doi.org/10.1073/pnas.1515024112
dc.identifierProceedings Of The National Academy Of Sciences Of The United States Of America, p. 14054–14059, 2015.
dc.identifier1091-6490
dc.identifierhttp://hdl.handle.net/11449/131658
dc.identifier10.1073/pnas.1515024112
dc.identifier26494285
dc.identifier0000-0002-3034-6497
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8780937
dc.descriptionFlavin mononucleotide (FMN) riboswitches are genetic elements, which in many bacteria control genes responsible for biosynthesis and/or transport of riboflavin (rib genes). Cytoplasmic riboflavin is rapidly and almost completely converted to FMN by flavokinases. When cytoplasmic levels of FMN are sufficient (high levels), FMN binding to FMN riboswitches leads to a reduction of rib gene expression. We report here that the protein RibR counteracts the FMN-induced turn-off activities of both FMN riboswitches in Bacillus subtilis, allowing rib gene expression even in the presence of high levels of FMN. The reason for this secondary metabolic control by RibR is to couple sulfur metabolism with riboflavin metabolism.
dc.descriptionDepartment of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, 68163 Mannheim, Germany; Department of Bioprocess and Biotechnology, School of Pharmaceutical Sciences, Universidade Estadual Paulista (UNESP), 14801-902 Araraquara, Brazil
dc.descriptionDepartment of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, 68163 Mannheim, Germany
dc.descriptionInstitute of Molecular Systems Biology, Eidgenössische Technische Hochschule (ETH) Zürich, 8093 Zürich, Switzerland
dc.descriptionDepartment of Biology, Technical University Darmstadt, 64287 Darmstadt, Germany
dc.descriptionDepartment of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, 68163 Mannheim, Germany
dc.descriptionDepartment of Biotechnology, Institute for Technical Microbiology, Hochschule Mannheim, 68163 Mannheim, Germany; Department of Bioprocess and Biotechnology, School of Pharmaceutical Sciences, Universidade Estadual Paulista (UNESP), 14801-902 Araraquara, Brazil
dc.format14054–14059
dc.languageeng
dc.relationProceedings Of The National Academy Of Sciences Of The United States Of America
dc.relation6,092
dc.rightsAcesso restrito
dc.sourcePubMed
dc.subjectBacillus subtilis
dc.subjectFmn riboswitch
dc.subjectRibr
dc.subjectFlavin mononucleotide
dc.subjectRiboflavin
dc.titleA dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis
dc.typeArtigo


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