Mutagenicity and chemopreventive activities of Astronium species assessed by Ames test

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorCentro Universitário de Araraquara (UNIARA)
dc.creatorResende, Flávia Aparecida [UNESP]
dc.creatorCampos, Debora Leite [UNESP]
dc.creatorda Silva, Viviane Cândida [UNESP]
dc.creatorGrandis, Rone Aparecido de [UNESP]
dc.creatorSouza, Leonardo Perez [UNESP]
dc.creatorLeonardo Junior, Carlos Sérgio [UNESP]
dc.creatorda Rocha, Cláudia Quintino [UNESP]
dc.creatordos Santos, Lourdes Campaner [UNESP]
dc.creatorVilegas, Wagner [UNESP]
dc.creatorVaranda, Eliana Aparecida [UNESP]
dc.date2015-12-07T15:34:36Z
dc.date2015-12-07T15:34:36Z
dc.date2015
dc.date.accessioned2023-09-12T07:34:11Z
dc.date.available2023-09-12T07:34:11Z
dc.identifierhttp://dx.doi.org/10.1016/j.yrtph.2015.05.014
dc.identifierRegulatory Toxicology And Pharmacology : Rtp, v. 72, n. 3, p. 506-513, 2015.
dc.identifier1096-0295
dc.identifierhttp://hdl.handle.net/11449/131382
dc.identifier10.1016/j.yrtph.2015.05.014
dc.identifier7927877224326837
dc.identifier26002624
dc.identifier0000-0003-3032-2556
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8780663
dc.descriptionIn the neotropical savannah, Astronium species are used in popular medicine to treat allergies, inflammation, diarrhea and ulcers. Given that natural products are promising starting points for the discovery of novel potentially therapeutic agents, the aim of the present study was to investigate the mutagenic and antimutagenic activities of hydroalcoholic extracts of Astronium spp. The mutagenicity was determined by the Ames test on Salmonella typhimurium strains TA98, TA97a, TA100 and TA102. The antimutagenicity was tested against the direct-acting and indirect-acting mutagens. The results showed that none of the extracts induce any increase in the number of revertants, demonstrating the absence of mutagenic activity. On the other hand, the results on the antimutagenic potential showed a moderate inhibitory effect against NPD and a strong protective effect against B[a]P and AFB1. This study highlights the importance of screening species of Astronium for new medicinal compounds. The promising results obtained open up new avenues for further study and provide a better understanding the mechanisms by which these species act in protecting DNA from damage. However, further pharmacological and toxicological investigations of crude extracts of Astronium spp., as well as of its secondary metabolites, are necessary to determine the mechanism(s) of action to guarantee their safer and more effective application to human health.
dc.descriptionDepartment of Biological Sciences and Health, Centro Universitário de Araraquara, UNIARA, CEP 14801-340 Araraquara, São Paulo, Brazil; Department of Biological Sciences, Faculty of Pharmaceutical Sciences of Araraquara, UNESP-São Paulo State University, CEP 14801-902 Araraquara, São Paulo, Brazil
dc.descriptionDepartment of Biological Sciences, Faculty of Pharmaceutical Sciences of Araraquara, UNESP-São Paulo State University, CEP 14801-902 Araraquara, São Paulo, Brazil
dc.descriptionDepartment of Organic Chemistry, Chemistry Institute of Araraquara, UNESP-São Paulo State University, CEP 14801-970 Araraquara, São Paulo, Brazil
dc.descriptionUNESP-São Paulo State University, Experimental Campus of the Paulista Coast, CEP 11330-900 São Vicente, São Paulo, Brazil
dc.descriptionDepartment of Biological Sciences and Health, Centro Universitário de Araraquara, UNIARA, CEP 14801-340 Araraquara, São Paulo, Brazil; Department of Biological Sciences, Faculty of Pharmaceutical Sciences of Araraquara, UNESP-São Paulo State University, CEP 14801-902 Araraquara, São Paulo, Brazil. Electronic address: flaviabiomed@yahoo.com.br.
dc.descriptionDepartment of Biological Sciences, Faculty of Pharmaceutical Sciences of Araraquara, UNESP-São Paulo State University, CEP 14801-902 Araraquara, São Paulo, Brazil.
dc.descriptionDepartment of Organic Chemistry, Chemistry Institute of Araraquara, UNESP-São Paulo State University, CEP 14801-970 Araraquara, São Paulo, Brazil.
dc.descriptionUNESP-São Paulo State University, Experimental Campus of the Paulista Coast, CEP 11330-900 São Vicente, São Paulo, Brazil.
dc.format506-513
dc.languageeng
dc.publisherElsevier B. V.
dc.relationRegulatory Toxicology And Pharmacology : Rtp
dc.relation0,812
dc.rightsAcesso restrito
dc.sourcePubMed
dc.subjectAmes test
dc.subjectAntimutagenicity
dc.subjectAstronium spp.
dc.subjectMutagenicity
dc.titleMutagenicity and chemopreventive activities of Astronium species assessed by Ames test
dc.typeArtigo


Este ítem pertenece a la siguiente institución