Effects of intra-PAG infusion of ovine CRF on defensive behaviors in Swiss-Webster mice

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCarvalho-Netto, Eduardo F.
dc.creatorLitvin, Yoav
dc.creatorNunes-de-Souza, Ricardo L.
dc.creatorBlanchard, D. Caroline
dc.creatorBlanchard, Robert J.
dc.date2014-05-20T15:23:14Z
dc.date2016-10-25T17:57:08Z
dc.date2014-05-20T15:23:14Z
dc.date2016-10-25T17:57:08Z
dc.date2007-01-25
dc.date.accessioned2017-04-05T23:40:57Z
dc.date.available2017-04-05T23:40:57Z
dc.identifierBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 176, n. 2, p. 222-229, 2007.
dc.identifier0166-4328
dc.identifierhttp://hdl.handle.net/11449/34063
dc.identifierhttp://acervodigital.unesp.br/handle/11449/34063
dc.identifier10.1016/j.bbr.2006.10.003
dc.identifierWOS:000243677000006
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2006.10.003
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/878056
dc.descriptionThe midbrain dorsal periaqueductal gray (DPAG) is part of the brain defensive system involved in active defense reactions to threatening stimuli. Corticotrophin releasing factor (CRF) is a peptidergic neurotransmitter that has been strongly implicated in the control of both behavioral and endocrine responses to threat and stress. We investigated the effect of the nonspecific CRF receptor agonist, ovine CRF (oCRF), injected into the DPAG of mice, in two predator-stress situations, the mouse defense test battery (MDTB), and the rat exposure test (RET). In the MDTB, oCRF weakly modified defensive behaviors in mice confronted by the predator (rat); e.g. it increased avoidance distance when the rat was approached and escape attempts (jump escapes) in forced contact. In the RET, drug infusion enhanced duration in the chamber while reduced tunnel and surface time, and reduced contact with the screen which divides the subject and the predator. oCRF also reduced both frequency and duration of risk assessment (stretch attend posture: SAP) in the tunnel and tended to increase freezing. These findings suggest that patterns of defensiveness in response to low intensity threat (RET) are more sensitive to intra-DPAG oCRF than those triggered by high intensity threats (MDTB). Our data indicate that CRF systems may be functionally involved in unconditioned defenses to a predator, consonant with a role for DPAG CRF systems in the regulation of emotionality. (c) 2006 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectalpha CRF
dc.subjectDPAG
dc.subjectdefensive behaviors
dc.subjectmice
dc.subjectMDTB and RET
dc.titleEffects of intra-PAG infusion of ovine CRF on defensive behaviors in Swiss-Webster mice
dc.typeOtro


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