Bone morphogenetic proteins: promising molecules for bone healing, bioengineering, and regenerative medicine

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal Fluminense (UFF)
dc.creatorCarreira, Ana Claudia Oliveira
dc.creatorZambuzzi, Willian Fernando [UNESP]
dc.creatorRossi, Mariana Correa [UNESP]
dc.creatorAstorino Filho, Renato
dc.creatorSogayar, Mari Cleide
dc.creatorGranjeiro, José Mauro
dc.date2015-12-07T15:33:00Z
dc.date2015-12-07T15:33:00Z
dc.date2015
dc.date.accessioned2023-09-12T07:31:51Z
dc.date.available2023-09-12T07:31:51Z
dc.identifierhttp://dx.doi.org/10.1016/bs.vh.2015.06.002
dc.identifierVitamins And Hormones, v. 99, p. 293-322, 2015.
dc.identifier0083-6729
dc.identifierhttp://hdl.handle.net/11449/131245
dc.identifier10.1016/bs.vh.2015.06.002
dc.identifier26279381
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8780526
dc.descriptionBone morphogenetic proteins (BMPs), glycoproteins secreted by some cells, are members of the TGF-β superfamily that have been implicated in a wide variety of roles. Currently, about 20 different BMPs have been identified and grouped into subfamilies, according to similarities with respect to their amino acid sequences. It has been shown that BMPs are secreted growth factors involved in mesenchymal stem cell differentiation, also being reported to control the differentiation of cancer stem cells. BMPs initiate signaling from the cell surface by binding to two different receptors (R: Type I and II). The heterodimeric formation of type I R and II R may occur before or after BMP binding, inducing signal transduction pathways through SMADs. BMPs may also signal through SMAD-independent pathways via mitogen-activated protein kinases (ERK, p38MAPKs, JNK). BMPs may act in an autocrine or paracrine manner, being regulated by specific antagonists, namely: noggin and chordin. Genetic engineering allows the production of large amounts of BMPs for clinical use, and clinical trials have shown the benefits of FDA-approved recombinant human BMPs 2 and 7. Several materials from synthetic to natural sources have been tested as BMP carriers, ranging from hydroxyapatite, and organic polymers to collagen. Bioactive membranes doped with BMPs are promising options, acting to accelerate and enhance osteointegration. The development of smart materials, mainly based on biopolymers and bone-like calcium phosphates, appears to provide an attractive alternative for delivering BMPs in an adequately controlled fashion. BMPs have revealed a promising future for the fields of Bioengineering and Regenerative Medicine. In this chapter, we review and discuss the data on BMP structure, mechanisms of action, and possible clinical applications.
dc.descriptionBanco Nacional de Desenvolvimento Econômico e Social (BNDES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.descriptionFinanciadora de Estudos e Projetos (FINEP)
dc.descriptionMinistério da Ciência, Tecnologia e Inovação (MCTI)
dc.descriptionNUCEL-NETCEM (Cell and Molecular Therapy Center), Internal Medicine Department, School of Medicine, University of São Paulo, São Paulo, Brazil.
dc.descriptionDepartment of Chemistry and Biochemistry, Biosciences Institute, UNESP, Universidade Estadual Paulista, Botucatu, Brazil.
dc.descriptionNUCEL-NETCEM (Cell and Molecular Therapy Center), Internal Medicine Department, School of Medicine, University of São Paulo, São Paulo, Brazil; Chemistry Institute, Biochemistry Department, São Paulo, Brazil.
dc.descriptionBioengineering Division, National Institute of Metrology, Quality, and Technology, Duque de Caxias, Brazil; Department of Dental Materials, Dental School, Fluminense Federal University, Niteroi, Brazil. Electronic address: jmgranjeiro@inmetro.gov.br.
dc.descriptionDepartment of Chemistry and Biochemistry, Biosciences Institute, UNESP, Universidade Estadual Paulista, Botucatu, Brazil.
dc.format293-322
dc.languageeng
dc.publisherElsevier B. V.
dc.relationVitamins And Hormones
dc.relation3.286
dc.relation0,939
dc.rightsAcesso restrito
dc.sourcePubMed
dc.subjectBioengineering and regenerative medicine
dc.subjectBone healing
dc.subjectBone morphogenetic proteins
dc.subjectBone regeneration
dc.subjectExtracellular matrix proteins
dc.subjectOsteogenic proteins
dc.subjectPeptide growth factors
dc.subjectRecombinant bmps
dc.subjectScaffolds
dc.titleBone morphogenetic proteins: promising molecules for bone healing, bioengineering, and regenerative medicine
dc.typeArtigo


Este ítem pertenece a la siguiente institución