Alternate current biosusceptometry for the assessment of gastric motility after proximal gastrectomy in rats: a feasibility study

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de Mato Grosso (UFMT)
dc.contributorUniversidade Federal do Ceará (UFC)
dc.contributorUniversidade de São Paulo (USP)
dc.creatorCalabresi, M. F. F. [UNESP]
dc.creatorQuini, C. C. [UNESP]
dc.creatorMatos, J. F. [UNESP]
dc.creatorMoretto, G. M. [UNESP]
dc.creatorAmerico, M. F.
dc.creatorGraça, J. R. V.
dc.creatorSantos, A. A.
dc.creatorOliveira, R. B.
dc.creatorPina, D. R. [UNESP]
dc.creatorMiranda, J. R. A. [UNESP]
dc.date2015-12-07T15:32:49Z
dc.date2015-12-07T15:32:49Z
dc.date2015
dc.date.accessioned2023-09-12T07:31:32Z
dc.date.available2023-09-12T07:31:32Z
dc.identifierhttp://dx.doi.org/10.1111/nmo.12660
dc.identifierNeurogastroenterology And Motility : The Official Journal Of The European Gastrointestinal Motility Society, v. 27, n. 11, p. 1613-1620, 2015.
dc.identifier1365-2982
dc.identifierhttp://hdl.handle.net/11449/131226
dc.identifier10.1111/nmo.12660
dc.identifier26303680
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8780507
dc.descriptionThis study proposes an experimental model to assess the consequences of gastric surgeries on gastric motility. We investigated the effects of proximal gastrectomy (PG) using a non-invasive technique (alternate current biosusceptometry [ACB]) on gastric contractility (GC), gastric emptying (GE), and orocecal transit (OCT) after the ingestion of liquids and solids in rats. Twenty-four male rats were subjected to gastric motility assessment before and after the PG procedure. The GE and OCT results are expressed as the mean time of gastric emptying (MGET) and cecum arrival (MCAT). The GC recordings are presented as the frequency and amplitude of contractions. Mean time of gastric emptying after solid meals were significantly different (p < 0.001) between control and PG (113 ± 5 to 99 ± 6 min). Mean time of cecum arrival ranged from 265 ± 9 to 223 ± 11 min (p < 0.001) and 164 ± 9 to 136 ± 17 min (p < 0.050) for solid and liquid meals, respectively. The assessment of GC showed that surgery decreased the phasic frequency (4.4 ± 0.4 to 3.0 ± 1.1 cpm, p < 0.050) and increased the amplitude of contractions (3.6 ± 2.7 to 7.2 ± 3.0 V/s, p < 0.050). No significant difference was found in tonic frequency. The ACB system was able to assess GE, OCT, and GC in gastrectomized rats. Overall, PG accelerated GE and gastrointestinal transit, likely due to the increase in both intragastric pressure and amplitude contraction. Our data presented an efficient model to investigate functional consequences from gastric surgeries that will allow further studies involving different procedures.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionDepartamento de Física e Biofísica, Instituto de Biociências de Botucatu, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
dc.descriptionInstituto de Ciências Biológicas e da Saúde, UFMT-Universidade Federal de Mato Grosso, Barra do Garças, Mato Grosso, Brazil.
dc.descriptionDepartamento de Fisiologia, Faculdade de Medicina de Sobral, UFC-Universidade Federal do Ceará, Sobral, Ceará, Brazil.
dc.descriptionDepartamento de Fisiologia e Farmacologia, Faculdade de Medicina, UFC-Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
dc.descriptionDepartamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, USP-Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
dc.descriptionDepartamento de Doenças Tropicais e Diagnóstico por Imagem, Faculdade de Medicina de Botucatu, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
dc.descriptionDepartamento de Física e Biofísica, Instituto de Biociências de Botucatu, UNESP-Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
dc.descriptionDepartamento de Doenças Tropicais e Diagnóstico por Imagem, Faculdade de Medicina de Botucatu, UNESP - Universidade Estadual Paulista, Botucatu, São Paulo, Brazil.
dc.format1613-1620
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationNeurogastroenterology And Motility : The Official Journal Of The European Gastrointestinal Motility Society
dc.rightsAcesso restrito
dc.sourcePubMed
dc.subjectAc biosusceptometry
dc.subjectGastric contractility
dc.subjectGastric emptying
dc.subjectGastric motility
dc.subjectProximal gastrectomy
dc.titleAlternate current biosusceptometry for the assessment of gastric motility after proximal gastrectomy in rats: a feasibility study
dc.typeArtigo


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