Oxidative stress and inflammatory response biomarkers in dogs with mammary carcinoma

dc.contributorUniversidade Federal de Santa Maria (UFSM)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de Franca (UNIFRAN)
dc.contributorUniversidade do Oeste de Santa Catarina (UNOESC)
dc.contributorUniversidade Luterana do Brasil
dc.contributorUniversidade do Estado de Santa Catarina (UDESC)
dc.creatorMachado, Vanessa S.
dc.creatorCrivellenti, Leandro Z. [UNESP]
dc.creatorBottari, Nathieli B.
dc.creatorTonin, Alexandre A.
dc.creatorPelinson, Luana P.
dc.creatorBorin-Crivellenti, Sofia [UNESP]
dc.creatorSantana, Aureo E. [UNESP]
dc.creatorTorbitz, Vanessa D.
dc.creatorMoresco, Rafael N.
dc.creatorDuarte, Thiago
dc.creatorDuarte, Marta M M F
dc.creatorSchetinger, Maria Rosa C
dc.creatorMorsch, Vera M.
dc.creatorJaques, Jeandre A.
dc.creatorTinucci-Costa, Mirela [UNESP]
dc.creatorDa Silva, Aleksandro S.
dc.date2015-12-07T15:32:18Z
dc.date2015-12-07T15:32:18Z
dc.date2015
dc.date.accessioned2023-09-12T07:30:37Z
dc.date.available2023-09-12T07:30:37Z
dc.identifierhttp://dx.doi.org/10.1016/j.prp.2015.06.011
dc.identifierPathology, Research And Practice, v. 211, n. 9, p. 677-681, 2015.
dc.identifier1618-0631
dc.identifierhttp://hdl.handle.net/11449/131177
dc.identifier10.1016/j.prp.2015.06.011
dc.identifier26166177
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8780458
dc.descriptionMammary carcinoma is the most common cancer that affects dogs, and in many cases it leads to death. Thus, given the importance of this disease, to clarify its pathogenesis is an important measure. In this sense, the aim of this study was to investigate the levels of cytokines and nitric oxide (NO), oxidative and antioxidant status, as well as the activity of adenosine deaminase (ADA) and butyrylcholinesterase (BChE) in dogs diagnosed with mammary carcinoma. With this purpose, thirty-three (33) serum samples from female dogs with histopathological diagnosis of mammary carcinoma, without evidence of metastasis, were used (group B). The material was classified based on the degree of malignancy, as follows: subgroup B1 (low-grade malignancy; n=26) and subgroup B2 (high grade of malignancy; n=7). Serum samples from healthy females (group A; n=10) were used as negative control. Our results showed that levels of cytokines (TNF-α, INF-γ, IL-1, and IL-6), NOx (nitrite/nitrate), AOPP (protein oxidation), and FRAP (antioxidant power) were significantly (P<0.05) increased in dogs with mammary carcinoma (group B), when compared with group A. On the other hand, ADA activity was significantly decreased (P<0.05) in both subgroups B1 and B2, when compared with group A. BChE activity, however, was reduced (P<0.05) only in subgroup B2 when compared with group A and subgroup B1. Unlike other variables, NO, AOPP, and IFN-γ were influenced by the degree of tumor malignancy, i.e., their levels were even higher in subgroup B2. Therefore, based on these results, we can conclude that all variables investigated are related to the pathogenesis of this disease, since they were altered in dogs with mammary tumor. Additionally, we suggest that ADA activity had an anti-inflammatory effect on these tumor samples, probably in order to modulate the inflammatory response.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionDepartment of Microbiology and Parasitology, Universidade Federal de Santa Maria (UFSM), Brazil
dc.descriptionDepartment of Veterinary Clinic and Surgery, São Paulo State University (UNESP), Jaboticabal, Brazil
dc.descriptionDepartment of Veterinary Clinic and Surgery, Franca University (UNIFRAN), Franca, Brazil
dc.descriptionDepartment of Biochemistry and Molecular Biology, UFSM, Santa Maria, RS, Brazil
dc.descriptionUniversidade do Oeste de Santa Catarina (UNOESC), Xanxerê, Brazil
dc.descriptionDepartment of Clinical and Toxicological Analysis, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil
dc.descriptionDepartment of Farmacology, UFSM, Santa Maria, RS, Brazil
dc.descriptionUniversidade Luterana do Brasil, Santa Maria, RS, Brazil
dc.descriptionLaboraroty of General Biochemistry and Microorganisms, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil
dc.descriptionDepartment of Animal Science, Universidade do Estado de Santa Catarina (UDESC), Chapecó, SC, Brazil.
dc.descriptionDepartment of Veterinary Clinic and Surgery, São Paulo State University (UNESP), Jaboticabal, Brazil
dc.descriptionFAPESP: 2011/08416-6
dc.descriptionFAPESP: 2011/11355-9
dc.format677-681
dc.languageeng
dc.publisherElsevier B. V.
dc.relationPathology, Research And Practice
dc.rightsAcesso restrito
dc.sourcePubMed
dc.subjectBreast cancer
dc.subjectImmune response
dc.subjectOxidative stress
dc.subjectPathogenesis
dc.titleOxidative stress and inflammatory response biomarkers in dogs with mammary carcinoma
dc.typeArtigo


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