Norepinephrine responses in rat renal and femoral veins are reinforced by vasoconstrictor prostanoids

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorFaculdade de Medicina de Marília (FAMEMA)
dc.creatorSouza Rossignoli, Patrícia de [UNESP]
dc.creatorYamamoto, Fernanda Zocatelli
dc.creatorPereira, Oduvaldo Câmara Marques [UNESP]
dc.creatorChies, Agnaldo Bruno
dc.date2015-12-07T15:31:20Z
dc.date2015-12-07T15:31:20Z
dc.date2015
dc.date.accessioned2023-09-12T07:28:45Z
dc.date.available2023-09-12T07:28:45Z
dc.identifierhttp://dx.doi.org/10.1016/j.vph.2015.06.017
dc.identifierVascular Pharmacology, v. 72, p. 93-100, 2015.
dc.identifier1879-3649
dc.identifierhttp://hdl.handle.net/11449/131069
dc.identifier10.1016/j.vph.2015.06.017
dc.identifier26141930
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8780350
dc.descriptionNorepinephrine (NE) responses are larger in renal and femoral veins compared to phenylephrine (PE). These differences may be due to the subtypes of adrenoceptor involved in these responses or to the involvement of local modulatory mechanisms. Therefore, the present study investigated in organ bath the adrenoceptor subtypes involved in the NE and PE responses in both renal and femoral veins as well as the influence of local mechanisms related to NO and to prostanoids upon these responses. The obtained data showed that the NE responses in these veins were not significantly modified by the selective inhibition of β1 or β2-adrenoceptors as well as AT1 or AT2 receptors. However, yohimbine reduced the NE Rmax in renal veins and, in parallel, right shifted the NE concentration-response curves in femoral veins. In both veins, prazosin reduced the NE Rmax and the clonidine induced a measurable contraction. The endothelium removal attenuated the NE responses in femoral veins, thereby abolishing the differences of NE and PE responses. Furthermore, the NE responses in renal and femoral veins were attenuated by indomethacin, which suppressed the statistical difference in relation to the PE response. In conclusion, a synergism between α1- and α2-adrenoceptors is essential to assure full NE contractile responses in both renal and femoral veins. Thus, by acting simultaneously in these adrenoceptors, NE induces more pronounced contractile responses, in comparison to PE, not only in renal but also in femoral veins. Moreover, this pronounced NE response in both renal and femoral veins appears to involve endothelium-derived vasoconstrictor prostanoids.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionDepartment of Physiotherapy and Occupational Therapy, São Paulo State University, UNESP, SP, Brazil.
dc.descriptionLaboratory of Pharmacology, Faculty of Medicine of Marília, SP, Brazil.
dc.descriptionDepartment of Pharmacology, Institute of Biosciences, São Paulo State University, UNESP, SP, Brazil.
dc.descriptionLaboratory of Pharmacology, Faculty of Medicine of Marília, SP, Brazil.
dc.descriptionDepartment of Physiotherapy and Occupational Therapy, São Paulo State University, UNESP, SP, Brazil.
dc.descriptionDepartment of Pharmacology, Institute of Biosciences, São Paulo State University, UNESP, SP, Brazil.
dc.descriptionFAPESP: 2011/02097-6
dc.format93-100
dc.languageeng
dc.publisherElsevier B. V.
dc.relationVascular Pharmacology
dc.rightsAcesso restrito
dc.sourcePubMed
dc.subject(r)-(−)-phenylephrine hydrochloride (pubchem cid: 5284443)
dc.subject(±)-isoproterenol hydrochloride (pubchem cid: 5807)
dc.subjectAcetylcholine chloride (pubchem cid: 6060)
dc.subjectAdrenoceptor
dc.subjectAtenolol (pubchem cid: 2249)
dc.subjectClonidine hydrochloride (pubchem cid: 20179)
dc.subjectEndothelin 1 (pubchem cid: 44284481)
dc.subjectIci 118,551 hydrochoride (pubchem cid: 46704341)
dc.subjectIndomethacin (pubchem cid: 3715)
dc.subjectLosartan potassium (pubchem cid: 11751549)
dc.subjectN(ω)-nitro-l-arginine methyl ester hydrochloride (pubchem cid: 39836)
dc.subjectNorepinephrine
dc.subjectPd 123,319 di(trifluoroacetate) salt hydrate (pubchem cid: 5311345)
dc.subjectPhenylephrine
dc.subjectPrazosin hydrochloride (pubchem cid: 68546)
dc.subjectProstanoid
dc.subjectVein
dc.subjectYohimbine hydrochloride (pubchem cid: 6169)
dc.subjectL-(−)-norepinephrine (+)-bitartrate salt monohydrate (pubchem cid: 24847757)
dc.titleNorepinephrine responses in rat renal and femoral veins are reinforced by vasoconstrictor prostanoids
dc.typeArtigo


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