A review of pharmacokinetic parameters of metabolites and prodrugs

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorCampos, Michel Leandro de
dc.creatorPadilha, Elias Carvalho
dc.creatorPeccinini, Rosângela Gonçalves [UNESP]
dc.date2015-12-07T15:31:08Z
dc.date2015-12-07T15:31:08Z
dc.date2014
dc.date.accessioned2023-09-12T07:28:19Z
dc.date.available2023-09-12T07:28:19Z
dc.identifierhttp://www.eurekaselect.com/121002/article
dc.identifierDrug Metabolism Letters, v. 7, n. 2, p. 105-116, 2014.
dc.identifier1874-0758
dc.identifierhttp://hdl.handle.net/11449/131046
dc.identifier1066743423929093
dc.identifier24628402
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8780328
dc.descriptionIn drug discovery and development, the kinetic study of active metabolites plays an important role, helping to define the time course of the drug in the body and its activity or toxicity. After a pharmacokinetics assessment of a drug and its metabolite or a prodrug and its parent-drug, several parameters can be calculated. In some cases, achieving the objective of the study does not require all possible parameters to be calculated. When parameters are calculated, it is essential that their denotations are widely accepted and used. However, some parameters undergo a certain variability of denotation, which may confuse some readers. Thus, this review summarizes the current published data for experimental pharmacokinetic parameters of metabolites and the calculations involved in simple metabolite pharmacokinetic studies. It also evaluates the most common pharmacokinetic parameters in the literature and suggests metabolite parameters that could be determined to help advance metabolite kinetic models.
dc.descriptionSao Paulo State University - UNESP School of Pharmaceutical Sciences Rodovia Araraquara-Jau Km. 01 s/n, City: Araraquara, State: Sao Paulo, Zip code: 14801-902; Brazil. michelcampos7@yahoo.com.br.
dc.descriptionSao Paulo State University - UNESP School of Pharmaceutical Sciences Rodovia Araraquara-Jau Km. 01 s/n, City: Araraquara, State: Sao Paulo, Zip code: 14801-902; Brazil. michelcampos7@yahoo.com.br.
dc.format105-116
dc.languageeng
dc.publisherDrug Metabolism Letters
dc.relationDrug Metabolism Letters
dc.rightsAcesso restrito
dc.sourcePubMed
dc.subjectMetabolite kinetics
dc.subjectpharmacokinetic parameters
dc.subjectpreclinical pharmacokinetics
dc.subjectprodrug pharmacokinetics
dc.titleA review of pharmacokinetic parameters of metabolites and prodrugs
dc.typeArtigo


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