Brasil | Artigo

Pharmacokinetics of tetracycline in plasma, synovial fluid and milk using single intravenous and single intravenous regional doses in dairy cattle with papillomatous digital dermatitis

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.creatorRodrigues, Celso Antonio [UNESP]
dc.creatorHussni, Carlos Alberto [UNESP]
dc.creatorNascimento, Elizabeth de Souza
dc.creatorEsteban, Cláudia
dc.creatorPerri, Sílvia Helena Venturoli
dc.date2015-12-07T15:30:02Z
dc.date2015-12-07T15:30:02Z
dc.date2010
dc.date.accessioned2023-09-12T07:25:36Z
dc.date.available2023-09-12T07:25:36Z
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2885.2009.01138.x
dc.identifierJournal Of Veterinary Pharmacology And Therapeutics, v. 33, n. 4, p. 363-370, 2010.
dc.identifier1365-2885
dc.identifierhttp://hdl.handle.net/11449/130898
dc.identifier10.1111/j.1365-2885.2009.01138.x
dc.identifier4663463575469428
dc.identifier6020984937849801
dc.identifier20646198
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8780186
dc.descriptionThe purpose of this study was to compare the pharmacokinetics of tetracycline in plasma, synovial fluid, and milk following either a single systemic intravenous (i.v.) injection or a single i.v. regional antibiosis (IVRA) administration of tetracycline hydrochloride to dairy cattle with papillomatous digital dermatitis (PDD). To this end, plasma and synovial fluid tetracycline concentrations were compared with the minimal inhibitory concentration (MIC) values of the major bacteria, which are known to cause digital diseases and thus assess its efficacy in PDD. Residual tetracycline concentrations in milk from cows treated by both methods were also determined. Twelve Holstein cows with various stages of PDD were randomly assigned to two groups of six animals. Group 1 received a single systemic i.v. injection of 10 mg/kg of tetracycline hydrochloride. Group 2 received 1000 mg of tetracycline hydrochloride by IVRA of the affected limb. Blood, synovial fluid and milk samples were taken prior to tetracycline administration (time 0 control), and then at 22, 45 and 82 min, and 2, 3, 4, 6, 8, 12, 24, 48, 72, 96, and 120 h following drug administration. Tetracycline concentrations were determined by high-performance liquid chromatography. Mean tetracycline plasma and milk concentrations in Group 1 were higher than Group 2. The opposite was observed for synovial fluid concentrations. Group 2 synovial fluid concentrations were higher than the MIC value over 24 h for the bacteria most frequently responsible for claw disease. Compared with i.v. administration, IVRA administration of tetracycline produced very high synovial fluid and low plasma and milk concentrations.
dc.descriptionFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.descriptionClinic, Surgery and Animal Reproduction, University of São Paulo State, UNESP, São Paulo, Brazil
dc.descriptionVeterinary Surgery and Anesthesia, University of São Paulo State/UNESP, São Paulo, Brazil
dc.descriptionDepartment of Clinical And Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil
dc.descriptionSupport, Production and Animal Health, University of São Paulo State, São Paulo, Brazil.
dc.descriptionClinic, Surgery and Animal Reproduction, University of São Paulo State, UNESP, São Paulo, Brazil
dc.descriptionVeterinary Surgery and Anesthesia, University of São Paulo State/UNESP, São Paulo, Brazil
dc.descriptionSupport, Production and Animal Health, University of São Paulo State, São Paulo, Brazil.
dc.descriptionFUNDUNESP: 00012⁄02-DFP
dc.format363-370
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationJournal Of Veterinary Pharmacology And Therapeutics
dc.relation0,700
dc.rightsAcesso restrito
dc.sourcePubMed
dc.titlePharmacokinetics of tetracycline in plasma, synovial fluid and milk using single intravenous and single intravenous regional doses in dairy cattle with papillomatous digital dermatitis
dc.typeArtigo


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