Effect of metoclopramide, ranitidine, and droperidol on the lower sphincter of the esophagus. Experimental study on the opossum (Didelphis albiventris)

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorHenry, M. A. [UNESP]
dc.creatorAthanasio, E. I. [UNESP]
dc.date2015-12-07T15:29:21Z
dc.date2015-12-07T15:29:21Z
dc.date1994
dc.date.accessioned2023-09-12T07:23:33Z
dc.date.available2023-09-12T07:23:33Z
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0004-2803&lng=en&nrm=iso
dc.identifierArquivos De Gastroenterologia, v. 31, n. 3, p. 103-107, 1994.
dc.identifier0004-2803
dc.identifierhttp://hdl.handle.net/11449/130788
dc.identifier7748101
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8780087
dc.descriptionElectromanometric measures of the gastroesophageal junction were performed in 20 adult, male and female, anesthetised opossums. The electromanometric examinations were performed according the intermitent pull through technique. The research was divided in four groups, according to the drug to be analysed: group 1 (20 animals) IM injection of physiological solution (control group); group 2 (20 animals) IM injection of metoclopramide; group 3 (20 animals) IM injection of ranitidine; group 4 (20 animals) IM injection of droperidol. Electromanometry was done 15 minutes before the drug injection, just after the injection and 15, 30, 45 and 60 minutes after the injection. In each one of the moments the pressure of the lower esophageal sphincter (LES-mmHg) was analysed. Considering LES pressure the results observed were: in group 1 it was not observed any significative alteration after IM injection of physiologic solution; in group 2 it was observed significative pressure increase, 15 minutes after metoclopramide IM injection; in group 3 it was observed pressure increase, being significative at 15 and 30 minutes after IM injection; in group 4 it was observed significative increase in LES pressure in every moment, 15 minutes after droperidol IM injection.
dc.descriptionUniversidade Estadual Paulista, Departamento de Cirurgia e Ortopedia, Faculdade de Medicina de Botucatu
dc.format103-107
dc.languagepor
dc.relationArquivos De Gastroenterologia
dc.relation0,396
dc.rightsAcesso restrito
dc.sourcePubMed
dc.titleEffect of metoclopramide, ranitidine, and droperidol on the lower sphincter of the esophagus. Experimental study on the opossum (Didelphis albiventris)
dc.typeArtigo


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