Synthesis and total 1H- and 13C-NMR assignment of cephem derivatives for use in ADEPT approaches

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Federal de São Carlos (UFSCar)
dc.contributorUniversidade de Franca
dc.creatorBlau, Lorena [UNESP]
dc.creatorMenegon, Renato Farina [UNESP]
dc.creatorFerreira, Elizabeth Igne
dc.creatorFerreira, Antonio Gilberto
dc.creatorBoffo, Elisangela Fabiana
dc.creatorTavares, Leila Aley
dc.creatorHeleno, Vladimir Constantino Gomes
dc.creatorChung, Man-Chin [UNESP]
dc.date2014-05-27T11:23:31Z
dc.date2014-05-27T11:23:31Z
dc.date2008-04-01
dc.date.accessioned2023-09-12T07:18:11Z
dc.date.available2023-09-12T07:18:11Z
dc.identifierhttp://dx.doi.org/10.3390/molecules13040841
dc.identifierMolecules. Basel: Molecular Diversity Preservation Int, v. 13, n. 4, p. 841-854, 2008.
dc.identifier1420-3049
dc.identifierhttp://hdl.handle.net/11449/130528
dc.identifier10.3390/molecules13040841
dc.identifierWOS:000255515900015
dc.identifier2-s2.0-43049167095
dc.identifier2-s2.0-43049167095.pdf
dc.identifier9734333607975413
dc.identifier0000-0003-4141-0455
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8779832
dc.descriptionWe report the synthesis and total NMR characterization of 5-thia-1-azabicyclo-[4.2.0]oct-2-ene-2-carboxylic acid-3-[[[(4″- nitrophenoxy)carbonyl]oxy]-methyl]-8-oxo-7-[(2-thienyloxoacetyl)amino] -diphenylmethyl ester-5-dioxide (5), a new cephalosporin derivative. This compound can be used as the carrier of a wide range of drugs containing an amino group. The preparation of the intermediate product, 5-thia-1-azabicyclo[4.2.0] oct-2-ene-2-carboxylic acid-3-[methyl 4-(6-methoxyquinolin-8-ylamino) pentylcarbamate]-8-oxo-7-[(2-thienyloxoacetyl)amino]-diphenylmethyl ester-5-dioxide (6), as well as the synthesis of the antimalarial primaquine prodrug 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid-3-[methyl 4-(6-methoxyquinolin-8-ylamino)pentylcarbamate]-8-oxo-7-[(2-thienyloxoacetyl) amino]- 5-dioxide (7) are also described, together with their total 1H- and 13C-NMR assignments. © 2008 by MDPI.
dc.descriptionDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, CP 502, 14801-902, Araraquara, SP
dc.descriptionDepartamento de Farmácia Faculdade de Ciências Farmacêuticas Universidade de São Paulo, CP 66083, 05389-970, São Paulo, SP
dc.descriptionDepartamento de Química Centro de Ciências Exatas e Tecnológicas Universidade Federal de São Carlos, CP 676, 13565-905, São Carlos, SP
dc.descriptionNúcleo de Pesquisas em Ciências Exatas e Tecnológicas Universidade de Franca, CP 82, 14404-600, Franca, SP
dc.descriptionDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, CP 502, 14801-902, Araraquara, SP
dc.format841-854
dc.languageeng
dc.publisherMolecular Diversity Preservation Int
dc.relationMolecules
dc.relation3.098
dc.relation0,855
dc.rightsAcesso aberto
dc.sourceScopus
dc.subject1H, 13C and 2D NMR
dc.subjectADEPT
dc.subjectCancer
dc.subjectCephalosporin
dc.subjectProdrug
dc.subjectcephalosporin derivative
dc.subjectprimaquine
dc.subjectprodrug
dc.subjectchemistry
dc.subjectisomerism
dc.subjectnuclear magnetic resonance spectroscopy
dc.subjectsynthesis
dc.subjectCephalosporins
dc.subjectIsomerism
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectPrimaquine
dc.subjectProdrugs
dc.titleSynthesis and total 1H- and 13C-NMR assignment of cephem derivatives for use in ADEPT approaches
dc.typeArtigo


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