Physiological and pathophysiological interactions between the respiratory central pattern generator and the sympathetic nervous system

dc.contributorIndiana University
dc.contributorPurdue University
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversity of Florida
dc.contributorUniversity of Bristol
dc.contributorUniversidade de São Paulo (USP)
dc.contributorCase Western Reserve University
dc.contributorDrexel University College of Medicine
dc.creatorMolkov, Yaroslav I.
dc.creatorZoccal, Daniel Breseghello [UNESP]
dc.creatorBaekey, David M.
dc.creatorAbdala, Ana Paula L.
dc.creatorMachado, Benedito Honório
dc.creatorDick, Thomas E.
dc.creatorPaton, Julian F. R.
dc.creatorRybak, Ilya A.
dc.date2015-11-03T15:28:08Z
dc.date2015-11-03T15:28:08Z
dc.date2014-01-01
dc.date.accessioned2023-09-12T07:05:56Z
dc.date.available2023-09-12T07:05:56Z
dc.identifierhttp://www.sciencedirect.com/science/article/pii/B978044463488700001X
dc.identifierBreathing, Emotion And Evolution. Amsterdam: Elsevier Science Bv, v. 212, p. 1-23, 2014.
dc.identifier0079-6123
dc.identifierhttp://hdl.handle.net/11449/129952
dc.identifier10.1016/B978-0-444-63488-7.00001-X
dc.identifierWOS:000349339500002
dc.identifier1958567557189244
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8779278
dc.descriptionRespiratory modulation seen in the sympathetic nerve activity (SNA) implies that the respiratory and sympathetic networks interact. During hypertension elicited by chronic intermittent hypoxia (CIH), the SNA displays an enhanced respiratory modulation reflecting strengthened interactions between the networks. In this chapter, we review a series of experimental and modeling studies that help elucidate possible mechanisms of sympatho-respiratory coupling. We conclude that this coupling significantly contributes to both the sympathetic baroreflex and the augmented sympathetic activity after exposure to CIH. This conclusion is based on the following findings. (1) Baroreceptor activation results in perturbation of the respiratory pattern via transient activation of postinspiratory neurons in the Botzinger complex (BotC). The same BotC neurons are involved in the respiratory modulation of SNA, and hence provide an additional pathway for the sympathetic baroreflex. (2) Under hypercapnia, phasic activation of abdominal motor nerves (AbN) is accompanied by synchronous discharges in SNA due to the common source of this rhythmic activity in the retrotrapezoid nucleus (RTN). CIH conditioning increases the CO2 sensitivity of central chemoreceptors in the RTN which results in the emergence of AbN and SNA discharges under normocapnic conditions similar to those observed during hypercapnia in naive animals. Thus, respiratory-sympathetic interactions play an important role in defining sympathetic output and significantly contribute to the sympathetic activity and hypertension under certain physiological or pathophysiological conditions, and the theoretical framework presented may be instrumental in understanding of malfunctioning control of sympathetic activity in a variety of disease states.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionIndiana University-Purdue University, Department of Mathematical Sciences
dc.descriptionUniversity of Florida, Department of Physiological Sciences
dc.descriptionUniversity of Bristol, School of Physiology and Pharmacology, Bristol Heart Institute
dc.descriptionUniversidade de São Paulo, Departmento of Fisiologia, Faculdade de Medicina de Ribeirão Preto
dc.descriptionCase Western Reserve University, Departments of Medicine and Neurosciences
dc.descriptionDrexel University College of Medicine, Department of Neurobiology and Anatomy
dc.descriptionUniversidade Estadual Paulista, Departamento de Fisiologia e Patologia, Faculdade de Odontologia de Araraquara
dc.format1-23
dc.languageeng
dc.publisherElsevier B.V.
dc.relationBreathing, Emotion And Evolution
dc.relation3.174
dc.relation1,444
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectRespiratory-sympathetic interactions
dc.subjectBaroreflex
dc.subjectChronic intermittent hypoxia
dc.subjectHypertension
dc.subjectModeling
dc.titlePhysiological and pathophysiological interactions between the respiratory central pattern generator and the sympathetic nervous system
dc.typeResenha


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