Insights into HLA-G genetics provided by worldwide haplotype diversity

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de Goiás (UFG)
dc.contributorMERIT
dc.contributorUniv Paris 05
dc.contributorUniversidade de São Paulo (USP)
dc.creatorCastelli, Erick C. [UNESP]
dc.creatorRamalho, Jaqueline [UNESP]
dc.creatorPorto, Iane O. P. [UNESP]
dc.creatorLima, Thalitta H. A. [UNESP]
dc.creatorFelicio, Leandro P.
dc.creatorSabbagh, Audrey
dc.creatorDonadi, Eduardo A.
dc.creatorMendes-Junior, CelsoT
dc.date2015-11-03T15:27:43Z
dc.date2015-11-03T15:27:43Z
dc.date2014-10-06
dc.date.accessioned2023-09-12T07:05:10Z
dc.date.available2023-09-12T07:05:10Z
dc.identifierhttp://journal.frontiersin.org/article/10.3389/fimmu.2014.00476/abstract
dc.identifierFrontiers In Immunology. Lausanne: Frontiers Research Foundation, v. 5, 27 p., 2014.
dc.identifier1664-3224
dc.identifierhttp://hdl.handle.net/11449/129907
dc.identifier10.3389/fimmu.2014.00476
dc.identifierWOS:000354476400001
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8779234
dc.descriptionHuman leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I genes, located within the major histocompatibility complex (MHC). HLA-G has been the target of most recent research regarding the function of class I non-classical genes. The main features that distinguish HLA-G from classical class I genes are (a) limited protein variability, (b) alternative splicing generating several membrane bound and soluble isoforms, (c) short cytoplasmic tail, (d) modulation of immune response (immune tolerance), and (e) restricted expression to certain tissues. In the present work, we describe the HLA-G gene structure and address the HLA-G variability and haplotype diversity among several populations around the world, considering each of its major segments [promoter, coding, and 3'untranslated region (UTR)] For this purpose, we developed a pipeline to reevaluate the 1000Genomes data and recover miscalled or missing genotypes and haplotypes. It became clear that the overall structure of the HLA-G molecule has been maintained during the evolutionary process and that most of the variation sites found in the HLA-G coding region are either coding synonymous or intronic mutations. In addition, only a few frequent and divergent extended haplotypes are found when the promoter, coding, and 3'UTRs are evaluated together. The divergence is particularly evident for the regulatory regions. The population comparisons confirmed that most of the HLA-G variability has originated before human dispersion from Africa and that the allele and haplotype frequencies have probably been shaped by strong selective pressures.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionPROPE/UNESP
dc.descriptionUniv Estadual Paulista, Sch Med Botucatu, Dept Pathol, BR-18618970 Botucatu, SP, Brazil
dc.descriptionUniv Fed Goias, Inst Biol Sci, Goiania, Go, Brazil
dc.descriptionMERIT, Inst Rech Dev, UMR 216, Paris, France
dc.descriptionUniv Paris 05, Sorbonne Paris Cite, Fac Pharm, Paris, France
dc.descriptionUniv Sao Paulo, Sch Med Ribeirao Preto, Dept Med, Div Clin Immunol, BR-14049 Ribeirao Preto, Brazil
dc.descriptionUniv Sao Paulo, Fac Filosofia Ciencias &Letras Ribeirao Preto, Dept Quim, BR-14049 Ribeirao Preto, Brazil
dc.descriptionUniv Estadual Paulista, Sch Med Botucatu, Dept Pathol, BR-18618970 Botucatu, SP, Brazil
dc.descriptionFAPESP: 2013/1708-42
dc.descriptionCNPq: 304471/2013-5
dc.descriptionCNPq: 304753/2009-2
dc.descriptionCNPq: 305493/2011-6
dc.format27
dc.languageeng
dc.publisherFrontiers Research Foundation
dc.relationFrontiers In Immunology
dc.relation5.511
dc.relation2,803
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectHLA-G
dc.subjectHaplotypes
dc.subjectPolymorphisms
dc.subjectVariability
dc.subjectGene structure and diversity
dc.subjectNon-classical HLA
dc.subject1000Genomes Project
dc.subjectSelective pressure
dc.titleInsights into HLA-G genetics provided by worldwide haplotype diversity
dc.typeArtigo


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