Recent advances in nanoparticle carriers for coordination complexes

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorSato, Mariana Rillo [UNESP]
dc.creatorSilva, Patricia Bento da [UNESP]
dc.creatorSouza, Rodrigo Alves de [UNESP]
dc.creatorSantos, Karen Cristina dos [UNESP]
dc.creatorChorilli, Marlus [UNESP]
dc.date2015-10-22T07:20:11Z
dc.date2015-10-22T07:20:11Z
dc.date2015-01-01
dc.date.accessioned2023-09-12T07:04:06Z
dc.date.available2023-09-12T07:04:06Z
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25579344
dc.identifierCurrent Topics In Medicinal Chemistry. Sharjah: Bentham Science Publ Ltd, v. 15, n. 4, p. 287-297, 2015.
dc.identifier1568-0266
dc.identifierhttp://hdl.handle.net/11449/129846
dc.identifier10.2174/1568026615666150108145614#sthash.9dA3x5hB.dpuf
dc.identifierWOS:000351013200004
dc.identifier1427125996716282
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8779175
dc.descriptionCoordination compounds are substances in which a central metal atom is bonded to nonmetal atoms, or groups of atoms, called ligands. Examples include vitamin B-12, hemoglobin, chlorophyll, dyes and pigments, as well as catalysts used in organic synthesis. Coordination compounds have received much attention in recent years. This interest was prompted by the discovery that several coordination compounds exhibit activity against bacteria, fungi and cancer. Some coordination compounds are not in clinical use, because of poor water solubility. Because they are unable to cross the lipid membranes of cells, bioavailability and efficacy are low. Some researchers have applied nanotechnology to coordination compounds, hoping to reduce the number of doses required and the severity of side effects, and also to improve biological activity. Nanotechnology can deliver active components in sufficient concentrations throughout treatment, guiding it to the desired location of action; conventional treatments do not meet these requirements. In this study we review some drug delivery systems based on nanotechnology, such as microemulsions (MEs), cyclodextrin (CD), polymeric nanoparticles (PN), solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), magnetic and gold nanoparticles (MNPs / AuNPs) and liquid crystalline systems (LC), and coordination compounds.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFCFAr
dc.descriptionPADC
dc.descriptionSchool of Pharmaceutical Sciences, São Paulo State University, Araraquara, Brazil
dc.descriptionSao Paulo State University, Inst Chemical, Araraquara, Brazil
dc.format287-297
dc.languageeng
dc.publisherBentham Science Publ Ltd
dc.relationCurrent Topics In Medicinal Chemistry
dc.relation3.374
dc.relation0,885
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBiological activity
dc.subjectCoordination compound
dc.subjectDrug delivery systems
dc.subjectMetallic complex
dc.subjectNanosystems
dc.subjectNanotechnology
dc.titleRecent advances in nanoparticle carriers for coordination complexes
dc.typeResenha


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