Effect of cryoprotectants on the reconstitution of silica nanoparticles produced by sol-gel technology

dc.contributorUniversity of Trás-osMontes e Alto Douro (UTAD)
dc.contributorUniversidade Fernando Pessoa
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidad de Barcelona
dc.contributorUniversidade de Coimbra FFUC
dc.creatorAndreani, Tatiana
dc.creatorKiill, Charlene Priscila [UNESP]
dc.creatorSouza, Ana Luiza R. de [UNESP]
dc.creatorFangueiro, Joana F.
dc.creatorDoktorovova, Slavomira
dc.creatorGarcia, Maria L.
dc.creatorGramiao, Maria Palmira Daflon [UNESP]
dc.creatorSilva, Amelia M.
dc.creatorSouto, Eliana B.
dc.date2015-10-21T20:58:56Z
dc.date2015-10-21T20:58:56Z
dc.date2015-04-01
dc.date.accessioned2023-09-12T06:53:44Z
dc.date.available2023-09-12T06:53:44Z
dc.identifierhttp://link.springer.com/article/10.1007%2Fs10973-014-4275-4
dc.identifierJournal Of Thermal Analysis And Calorimetry, v. 120, n. 1, p. 1001-1007, 2015.
dc.identifier1388-6150
dc.identifierhttp://hdl.handle.net/11449/129385
dc.identifier10.1007/s10973-014-4275-4
dc.identifierWOS:000352139800110
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8778725
dc.descriptionFreeze-drying has widely been applied to improve the stabilization of colloidal drug carriers. In the present study, the effect of cryoprotectants on the physicochemical characteristics of silica nanoparticles (SiNP) during the freeze-drying process has been extensively investigated. SiNP were synthesized by sol-gel technology and freeze-dried in the presence of sorbitol, trehalose, and/or mannitol at different concentrations and ratios. Dynamic light scattering (DLS), atomic force microscopy (AFM), X-ray diffraction analysis (XRD), and differential scanning calorimetry (DSC) have been used for particle characterization after freeze-drying. Based on the obtained results, SiNP in the presence of mannitol showed a more crystalline behavior in comparison to nanoparticles with sorbitol or trehalose (confirmed by DSC and XRD). SiNP in the presence of trehalose showed a more crystalline structure than SiNP in the presence of sorbitol. However, trehalose was more efficient in preserving the particle size of nanoparticles during the freeze-drying process. The optimal concentration of trehalose for preserving silica nanoparticles was 10 % at a ratio of (1:1). During the freeze-drying process, trehalose is able to replace water molecules due to the strong interaction via hydrogen bounds between silanol groups present in SiNP surface and the sugar, forming a stable layer around the particle and thus preserving the particle physical properties.
dc.descriptionFundação para a Ciência e a Tecnologia (FCT)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionEuropean Union Funds (FEDER/COMPETE)
dc.descriptionUniv Tras Os Montes &Alto Douro UTAD, Dept Biol &Environm, P-5001801 Vila Real, Portugal
dc.descriptionUTAD, Ctr Res &Technol Agro Environm &Biol Sci CITAB, Vila Real, Portugal
dc.descriptionUniv Fernando Pessoa, Res Ctr Biomed CEBIMED, P-4249004 Oporto, Portugal
dc.descriptionUNESP Univ Estadual Paulista, Dept Pharmaceut Sci, Sao Paulo, Brazil
dc.descriptionUniv Fernando Pessoa, Fac Hlth Sci, P-4200150 Oporto, Portugal
dc.descriptionUniv Barcelona, Fac Pharm, Dept Phys Chem, E-08028 Barcelona, Spain
dc.descriptionUniv Coimbra FFUC, Fac Pharm, Polo Ciencias Saude, P-3000548 Coimbra, Portugal
dc.descriptionUNESP Univ Estadual Paulista, Dept Pharmaceut Sci, Departamento de Farmacos e Médicamentos, Sao Paulo, Brazil
dc.descriptionFCT: SFRH/BD/60640/2009
dc.descriptionFCT: SFRH/BD/80335/2011
dc.descriptionFCT: SFRH/BD/60552/2009
dc.descriptionFCT: PTDC/SAU-FAR/113100/2009
dc.descriptionFCT: PEst-C/AGR/UI4033/2011
dc.descriptionFEDER/COMPETE: PTDC/SAU-FAR/113100/2009
dc.descriptionFEDER/COMPETE: PEst-C/AGR/UI4033/2011
dc.descriptionFEDER/COMPETE: FCOMP-01-0124-FEDER-022696
dc.format1001-1007
dc.languageeng
dc.publisherSpringer
dc.relationJournal Of Thermal Analysis And Calorimetry
dc.relation2.209
dc.relation0,587
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSilica nanoparticles
dc.subjectSol-gel
dc.subjectFreeze-drying
dc.subjectStability
dc.subjectCryoprotectants
dc.titleEffect of cryoprotectants on the reconstitution of silica nanoparticles produced by sol-gel technology
dc.typeArtigo


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