Brasil | Artigo

Ruthenium(II) complexes with hydroxypyridinecarboxylates: screening potential metallodrugs against Mycobacterium tuberculosis

dc.contributorUniversidade Federal de São Carlos (UFSCar)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributorUniversidade Federal de Uberlândia (UFU)
dc.creatorBarbosa, Marilia I. F.
dc.creatorCorrea, Rodrigo S.
dc.creatorPozzi, Lucas V.
dc.creatorLopes, Erica de O. [UNESP]
dc.creatorPavan, Fernando R. [UNESP]
dc.creatorLeite, Clarice Q. F. [UNESP]
dc.creatorEllena, Javier
dc.creatorMachado, Sergio de P.
dc.creatorVon Poelhsitz, Gustavo
dc.creatorBatista, Alzir A.
dc.date2015-10-21T20:56:26Z
dc.date2015-10-21T20:56:26Z
dc.date2015-01-08
dc.date.accessioned2023-09-12T06:53:25Z
dc.date.available2023-09-12T06:53:25Z
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0277538714005889
dc.identifierPolyhedron. Oxford: Pergamon-elsevier Science Ltd, v. 85, p. 376-382, 2015.
dc.identifier0277-5387
dc.identifierhttp://hdl.handle.net/11449/129367
dc.identifier10.1016/j.poly.2014.08.057
dc.identifierWOS:000347582900047
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8778707
dc.descriptionThree promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex [Ru(2-OHnic)(dppb)(bipy)PF6 (1), the 2-OHnic anion is coordinated by the O,O-chelating mode (via carboxylate group and phenolate oxygen), in the Ru(6-OHnic)(dppb)(bipy)]PF6 (2) a O-O chelation by the carboxylate group is observed for the 6-OHnic ligand and for the complex [Ru(3-OHpic)(dppb)(bipy))PF6 (3) a N,O-chelating mode (via carboxylate) occurs to the 3-OHpic anion. The compounds were evaluated for activity against Mycobacterium tuberculosis H(37)Rv ATCC 27294 using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO CCL-81 cell line. All the synthesized compounds exhibited good antimycobacterial activity and a completely lack of cytotoxicity activity, indicating a good selectivity index. (C) 2014 Elsevier Ltd. All rights reserved.
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.descriptionUniv Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil
dc.descriptionUniv Estadual Paulista, Dept Ciencias Biol, Fac Ciencias Farmaceut, BR-14800900 Araraquara, SP, Brazil
dc.descriptionUniv Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
dc.descriptionUniv Fed Rio de Janeiro, Inst Quim, BR-21941590 Rio De Janeiro, RJ, Brazil
dc.descriptionUniv Fed Uberlandia, Inst Quim, BR-38400902 Uberlandia, MG, Brazil
dc.descriptionDepartamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, CEP: 14800-900, Araraquara (SP) Brazil
dc.descriptionFAPESP: 2013/26559-4
dc.format376-382
dc.languageeng
dc.publisherElsevier B.V.
dc.relationPolyhedron
dc.relation2.067
dc.relation0,472
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectMycobacterium tuberculosis
dc.subjectCytotoxicity
dc.subjectRuthenium(II) complexes
dc.subjectMetallodrugs
dc.subjectHydroxypyridinecarboxylates
dc.titleRuthenium(II) complexes with hydroxypyridinecarboxylates: screening potential metallodrugs against Mycobacterium tuberculosis
dc.typeArtigo


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