A flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.creatorCabrera, Flavio C. [UNESP]
dc.creatorMelo, Antonio F. A. A.
dc.creatorSouza, Joao C. P. de
dc.creatorJob, Aldo E. [UNESP]
dc.creatorCrespilho, Frank N.
dc.date2015-10-21T20:50:22Z
dc.date2015-10-21T20:50:22Z
dc.date2015-01-01
dc.date.accessioned2023-09-12T06:52:37Z
dc.date.available2023-09-12T06:52:37Z
dc.identifierhttp://pubs.rsc.org/en/Content/ArticleLanding/2015/LC/C4LC01483A#!divAbstract
dc.identifierLab On A Chip, v. 15, n. 8, p. 1835-1841, 2015.
dc.identifier1473-0197
dc.identifierhttp://hdl.handle.net/11449/129322
dc.identifier10.1039/c4lc01483a
dc.identifierWOS:000352088400005
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8778662
dc.descriptionMagnetite decorated with gold nanoparticles (Fe3O4-AuNPs) is a ferrimagnetic material with unprecedented applications in immunosensors, as a contrast agent for imaging diagnosis, and for the photothermal ablation of tumor cells. Here, we show the preparation of controlled amounts of Fe3O4-AuNPs without organic solvents, surfactants, or heat treatment. For this, we have developed a customized natural-rubber-based microfluidic device (NRMD) as a flexible lab-on-a-chip for the decoration of Fe3O4 with AuNPs. With a novel NRMD configuration, monodisperse Fe3O4-NPs (phi = 10 nm) decorated with AuNPs (phi = 4 nm) were readily obtained. The AuNPs were homogenous in terms of their size and their distribution on the Fe3O4-NP surfaces. Furthermore, the lab-on-a-chip was projected with an internal system for magnetic separation, an innovation in terms of aqueous/carrier phase separation. Finally, the nanomaterials produced with this NRMD are free of organic solvents and surfactants, allowing them to be used directly for medical applications.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionBrazilian agency INEO
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionUNESP, FCT, Dept Fis Quim &Biol, Presidente Prudente, SP, Brazil
dc.descriptionUniv Sao Paulo, Inst Quim, Sao Carlos, SP, Brazil
dc.descriptionUNESP, FCT, Dept Fis Quim &Biol, Presidente Prudente, SP, Brazil
dc.descriptionFAPESP: 2013/14262-7
dc.descriptionFAPESP: 2013/04663-4
dc.descriptionCNPq: 306106/2013-2
dc.descriptionCNPq: 478525/2013-3
dc.descriptionFAPESP: 2011/23362-0
dc.format1835-1841
dc.languageeng
dc.publisherRoyal Soc Chemistry
dc.relationLab On A Chip
dc.relation5.995
dc.relation2,158
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.titleA flexible lab-on-a-chip for the synthesis and magnetic separation of magnetite decorated with gold nanoparticles
dc.typeArtigo


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