Advanced Molecular Surveillance of Hepatitis C Virus

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorInstituto de Diagnostico y Referencia Epidemiologicos
dc.creatorGoncalves Rossi, Livia Maria [UNESP]
dc.creatorEscobar-Gutierrez, Alejandro
dc.creatorRahal, Paula [UNESP]
dc.date2015-10-21T13:13:38Z
dc.date2015-10-21T13:13:38Z
dc.date2015-03-01
dc.date.accessioned2023-09-12T06:40:54Z
dc.date.available2023-09-12T06:40:54Z
dc.identifierhttp://www.mdpi.com/1999-4915/7/3/1153
dc.identifierViruses-basel. Basel: Mdpi Ag, v. 7, n. 3, p. 1153-1188, 2015.
dc.identifier1999-4915
dc.identifierhttp://hdl.handle.net/11449/128793
dc.identifier10.3390/v7031153
dc.identifierWOS:000351943000015
dc.identifierWOS000351943000015.pdf
dc.identifier7991082362671212
dc.identifier0000-0001-5693-6148
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8778139
dc.descriptionHepatitis C virus (HCV) infection is an important public health problem worldwide. HCV exploits complex molecular mechanisms, which result in a high degree of intrahost genetic heterogeneity. This high degree of variability represents a challenge for the accurate establishment of genetic relatedness between cases and complicates the identification of sources of infection. Tracking HCV infections is crucial for the elucidation of routes of transmission in a variety of settings. Therefore, implementation of HCV advanced molecular surveillance (AMS) is essential for disease control. Accounting for virulence is also important for HCV AMS and both viral and host factors contribute to the disease outcome. Therefore, HCV AMS requires the incorporation of host factors as an integral component of the algorithms used to monitor disease occurrence. Importantly, implementation of comprehensive global databases and data mining are also needed for the proper study of the mechanisms responsible for HCV transmission. Here, we review molecular aspects associated with HCV transmission, as well as the most recent technological advances used for virus and host characterization. Additionally, the cornerstone discoveries that have defined the pathway for viral characterization are presented and the importance of implementing advanced HCV molecular surveillance is highlighted.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionSao Paulo State University (UNESP) - Department of Biology, Institute of Bioscience, Language and Exact Science, Sao Jose do Rio Preto, SP 15054-000, Brazil
dc.descriptionInstituto de Diagnostico y Referencia Epidemiologicos, Mexico City 01480, Mexico
dc.descriptionSao Paulo State University (UNESP) - Department of Biology, Institute of Bioscience, Language and Exact Science, Sao Jose do Rio Preto, SP 15054-000, Brazil
dc.descriptionCAPES: 33004153079P9
dc.format1153-1188
dc.languageeng
dc.publisherMdpi Ag
dc.relationViruses-basel
dc.relation3.761
dc.relation1,805
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectHepatitis C virus
dc.subjectAdvanced molecular surveillance
dc.subjectMolecular epidemiology
dc.subjectMolecular characterization
dc.subjectHost factors
dc.titleAdvanced Molecular Surveillance of Hepatitis C Virus
dc.typeArtigo


Este ítem pertenece a la siguiente institución