Linking genetic and environmental factors in amphibian disease risk

dc.contributorCornell University
dc.contributorUniversity of Central Florida
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorSavage, Anna E.
dc.creatorBecker, Carlos G. [UNESP]
dc.creatorZamudio, Kelly R.
dc.date2015-10-21T13:13:24Z
dc.date2015-10-21T13:13:24Z
dc.date2015-07-01
dc.date.accessioned2023-09-12T06:40:36Z
dc.date.available2023-09-12T06:40:36Z
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/eva.12264/full
dc.identifierEvolutionary Applications. Hoboken: Wiley-blackwell, v. 8, n. 6, p. 560-572, 2015.
dc.identifier1752-4571
dc.identifierhttp://hdl.handle.net/11449/128775
dc.identifier10.1111/eva.12264
dc.identifierWOS:000356682200005
dc.identifierWOS000356682200005.pdf
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8778121
dc.descriptionA central question in evolutionary biology is how interactions between organisms and the environment shape genetic differentiation. The pathogen Batrachochytrium dendrobatidis (Bd) has caused variable population declines in the lowland leopard frog (Lithobates yavapaiensis); thus, disease has potentially shaped, or been shaped by, host genetic diversity. Environmental factors can also influence both amphibian immunity and Bd virulence, confounding our ability to assess the genetic effects on disease dynamics. Here, we used genetics, pathogen dynamics, and environmental data to characterize L.yavapaiensis populations, estimate migration, and determine relative contributions of genetic and environmental factors in predicting Bd dynamics. We found that the two uninfected populations belonged to a single genetic deme, whereas each infected population was genetically unique. We detected an outlier locus that deviated from neutral expectations and was significantly correlated with mortality within populations. Across populations, only environmental variables predicted infection intensity, whereas environment and genetics predicted infection prevalence, and genetic diversity alone predicted mortality. At one locality with geothermally elevated water temperatures, migration estimates revealed source-sink dynamics that have likely prevented local adaptation. We conclude that integrating genetic and environmental variation among populations provides a better understanding of Bd spatial epidemiology, generating more effective conservation management strategies for mitigating amphibian declines.
dc.descriptionNational Science Foundation (NSF)
dc.descriptionDoctoral Dissertation Improvement Grant
dc.descriptionPopulation Evolutionary Processes grant
dc.descriptionNational Geographic Society
dc.descriptionDepartment of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY, USA
dc.descriptionDepartment of Biology, University of Central Florida, Orlando, FL 32816, USA
dc.descriptionDepartment of Zoology, State University of Sao Paulo, Rio Claro, Brazil
dc.descriptionDoctoral Dissertation Improvement Grant: DEB-0909013
dc.descriptionPopulation Evolutionary Processes grant: DEB-0815315
dc.format560-572
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationEvolutionary Applications
dc.relation4.694
dc.relation2,676
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectAmphibian
dc.subjectConservation genetics
dc.subjectDisease biology
dc.subjectHost-parasite interactions
dc.subjectPopulation genetics
dc.titleLinking genetic and environmental factors in amphibian disease risk
dc.typeArtigo


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