Standard short-term diet ameliorates the lipid profile altered by a fructose-rich diet in rats

dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorCambri, L. T. [UNESP]
dc.creatorGhezzi, A. C. [UNESP]
dc.creatorArsa, G.
dc.creatorBotezelli, J. D. [UNESP]
dc.creatorMello, M. A. R. de [UNESP]
dc.date2015-10-21T13:13:22Z
dc.date2015-10-21T13:13:22Z
dc.date2015-08-01
dc.date.accessioned2023-09-12T06:40:33Z
dc.date.available2023-09-12T06:40:33Z
dc.identifierhttp://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=9817387&fileId=S2040174415001026
dc.identifierJournal Of Developmental Origins Of Health And Disease. Cambridge: Cambridge Univ Press, v. 6, n. 4, p. 335-341, 2015.
dc.identifier2040-1744
dc.identifierhttp://hdl.handle.net/11449/128772
dc.identifier10.1017/S2040174415001026
dc.identifierWOS:000357314000011
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8778118
dc.descriptionMarkers of metabolic abnormalities are commonly found in rodents fed a fructose-rich diet. The purpose of this study was to determine whether the administration of a short-term standard diet to rats is able to improve the lipid profile altered by a fructose-rich diet. The male pups, immediately after birth, were divided in three groups according to the diet for 90 days. Standard diet: a standard diet for the whole experimental period; fructose (60% fructose-rich diet): fructose-rich diet during the entire experimental period; fructose/standard (FS): fructose-rich diet from the neonatal period up to 60 days of age and standard diet from 60 to 90 days of age. A fructose-rich diet from the neonatal period to 60 days reduced weight gain (P<0.05), as well as the weight of adipose tissues in all the regions analyzed (epididymal, mesenteric, retroperitoneal and posterior subcutaneous), and it altered the lipid profile (elevation of triglycerides, total cholesterol, low density lipoprotein (LDL) cholesterol and very low density lipoprotein (VLDL) cholesterol; P<0.05). When a standard diet was administered after the fructose-rich diet, it was able to partially reverse changes to the lipid profile, as total cholesterol levels were significantly different in all the groups (P<0.05), and triglyceride and VLDL cholesterol levels were similar between the control and FS group. In summary, a fructose-rich diet altered the lipid profile, and a standard diet can partially reverse the changed parameters in short term.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionUniv Fed Mato Grosso, Dept Phys Educ, UFMT, BR-78060900 Cuiaba, MT, Brazil
dc.descriptionSao Paulo State Univ, UNESP, Dept Phys Educ, Rio Claro, SP, Brazil
dc.descriptionSao Paulo State Univ, UNESP, Dept Phys Educ, Rio Claro, SP, Brazil
dc.descriptionFAPESP: 08/53255-8
dc.format335-341
dc.languageeng
dc.publisherCambridge Univ Press
dc.relationJournal Of Developmental Origins Of Health And Disease
dc.relation2.215
dc.relation0,843
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbody weight
dc.subjectfructose-rich diet
dc.subjectlipid profile
dc.subjectmetabolic syndrome
dc.subjectstandard diet
dc.titleStandard short-term diet ameliorates the lipid profile altered by a fructose-rich diet in rats
dc.typeArtigo


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