Terminalia catappa L.: A medicinal plant from the Caribbean pharmacopeia with anti-Helicobacter pylori and antiulcer action in experimental rodent models

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniv Santa Cecilia
dc.creatorSilva, Laisa Pinheiro [UNESP]
dc.creatorAngelis, Celio Damacena de [UNESP]
dc.creatorBonamin, Flavia [UNESP]
dc.creatorKushima, Helio [UNESP]
dc.creatorMininel, Francisco Jose [UNESP]
dc.creatorSantos, Lourdes Campaner dos [UNESP]
dc.creatorDelella, Flavia Karina [UNESP]
dc.creatorFelisbino, Sergio Luis [UNESP]
dc.creatorVilegas, Wagner [UNESP]
dc.creatorMachado da Rocha, Lucia Regina [UNESP]
dc.creatorSantos Ramos, Matheus Aparecido dos [UNESP]
dc.creatorBauab, Tais Maria [UNESP]
dc.creatorToma, Walber
dc.creatorHiruma-Lima, Clelia Akiko [UNESP]
dc.date2015-10-21T13:11:15Z
dc.date2015-10-21T13:11:15Z
dc.date2015-01-15
dc.date.accessioned2023-09-12T06:37:11Z
dc.date.available2023-09-12T06:37:11Z
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0378874114008095
dc.identifierJournal Of Ethnopharmacology. Clare: Elsevier Ireland Ltd, v. 159, p. 285-295, 2015.
dc.identifier0378-8741
dc.identifierhttp://hdl.handle.net/11449/128587
dc.identifier10.1016/j.jep.2014.11.025
dc.identifierWOS:000348271500030
dc.identifier7927877224326837
dc.identifier3538253640602977
dc.identifier3814504901386844
dc.identifier0000-0002-8645-3777
dc.identifier0000-0003-3032-2556
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8777937
dc.descriptionEthnopharmacological relevance: Terminalia catappa L. (Combretaceae) is a medicinal plant listed as a pharmacopeia vegetable from Caribbean to treat gastritis. The objective of this study was to evaluate the gastroprotective and healing effect of the aqueous fraction (FrAq) obtained from the leaves of Terminalia catappa and to determine the antiulcer mechanism of action in experimental rodent models and its activity to Helicobacter pylori.Material and methods: In rodents, the FrAq was challenged by different necrotizing agents, such as absolute ethanol and ischemia-reperfusion injury. The antiulcer mechanism of action of FrAq was assessed and the healing effects of the fraction after seven and 14 days of treatment was evaluated by matrix metalloproteinase activity (MMP-2 and MMP-9). The toxicological effect of subacute treatment with FrAq during 14 days of treatment was also analyzed. The anti-Helicobacter pylori activity was determined by microdilution. The phytochemical study of the fraction was analyzed by experiments with FIA-ESI-IT-MSn (Direct Flow Analysis-ionization Electrospray Ion Trap Tandem Mass Spectrometry) and high performance liquid chromatography (HPLC) coupled to a photodiode array (PDA).Results: Oral treatment with FrAq (25 mg/kg) significantly decreased the number of ulcerative lesions induced by ethanol and ischemia/reperfusion injury. The action of FrAq was mediated by the activation of defensive mucosa-protective factors, such as increases in mucus production, the nitric oxide (NO) pathway and endogenous prostaglandins. Oral treatment with FrAq for seven and 14 days significantly reduced the lesion area (80% and 37%, respectively) compared to the negative control group. Analyses of MMP-9 and MMP-2 activity from gastric mucosa confirmed the accelerated gastric healing effect of FrAq. This extract also presented considerable activity against Helicobacter pylori. The mass spectrum and MS/MS of the aqueous fraction indicates the existence of many different phenolic compounds, including punicalagin, punicalin, and gallagic acid, among others.Conclusions: We concluded that FrAq from Terminalia catappa leaves has excellent preventive and curative effects on acute and chronic induced gastric ulcers and showed an important profile against Helicobacter pylori. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionUniv Estadual Paulista, UNESP, Dept Fisiol, Inst Biociencias, BR-18618970 Botucatu, SP, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, Dept Quim Organ, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, Dept Morfol, Inst Biociencias, BR-18618970 Botucatu, SP, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, BR-11330900 Sao Vicente, SP, Brazil
dc.descriptionUniv Santa Cecilia, BR-11045907 Santos, SP, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, Dept Ciencias Biol, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, Dept Fisiol, Inst Biociencias, BR-18618970 Botucatu, SP, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, Dept Quim Organ, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, Dept Morfol, Inst Biociencias, BR-18618970 Botucatu, SP, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, BR-11330900 Sao Vicente, SP, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, Dept Ciencias Biol, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.format285-295
dc.languageeng
dc.publisherElsevier B.V.
dc.relationJournal Of Ethnopharmacology
dc.relation3.115
dc.relation1,150
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectTerminalia catappa L.
dc.subjectCombretaceae
dc.subjectGastric healing action
dc.subjectHelicobacter pylori
dc.subjectMMP-9
dc.subjectMMP-2
dc.titleTerminalia catappa L.: A medicinal plant from the Caribbean pharmacopeia with anti-Helicobacter pylori and antiulcer action in experimental rodent models
dc.typeArtigo


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