Enhancing the versatility of alternate current biosusceptometry (ACB) through the synthesis of a dextrose-modified tracer and a magnetic muco-adhesive cellulose gel

dc.contributorUniv Copenhagen
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorMartins, Murillo L. [UNESP]
dc.creatorCalabresi, Marcos Felipe de Freitas [UNESP]
dc.creatorQuini, Caio César [UNESP]
dc.creatorMatos, Juliana F. [UNESP]
dc.creatorMiranda, José R. A. [UNESP]
dc.creatorSaeki, Margarida Juri [UNESP]
dc.creatorBordallo, Heloisa N.
dc.date2015-10-21T13:11:09Z
dc.date2015-10-21T13:11:09Z
dc.date2015-03-01
dc.date.accessioned2023-09-12T06:37:00Z
dc.date.available2023-09-12T06:37:00Z
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0928493114007838
dc.identifierMaterials Science &engineering C-materials For Biological Applications, v. 48, p. 80-85, 2015.
dc.identifier0928-4931
dc.identifierhttp://hdl.handle.net/11449/128577
dc.identifier10.1016/j.msec.2014.11.059
dc.identifierWOS:000348749200011
dc.identifier1802982806436894
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8777927
dc.descriptionAlternate Current Biosusceptometry (ACB) is a promising bio-magnetic method, radiation free and easily performed used for gastric emptying exams. Due to development on its sensitivity level, interesting nature, noninvasiveness and low cost it has attracted a lot of attention. In this work, magnetic nanoparticles of Mn-Zn ferrite as well as dextrose-modified nanoparticles were synthesized to be used as possible tracers in ACB gastric emptying exams. In addition, a magnetic muco-adhesive gel was obtained by modifying the ferrite nanoparticles with cellulose. Based on in-vivo tests in rats, we show that the pure ferrite nanoparticles, whose isoelectric point was found to be at pH = 3.2, present a great sensitivity to pH variations along the gastrointestinal tract, while the reduction of the isoelectric point by the dextrose modification leads to suitable nanoparticles for rapid gastric emptying examinations. On the other hand, the in-vivo tests show that the muco-adhesive cellulose gel presents substantial stomach adhesion and is a potential drug delivery system easily traceable by the ACB system. (C) 2014 Elsevier B.V. All rights reserved.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionScience Without Borders Program
dc.descriptionUniv Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark
dc.descriptionUniv Estadual Paulista, Inst Biociencias, BR-18618970 Botucatu, SP, Brazil
dc.descriptionUniv Estadual Paulista, Departamento de Física e Biofísica, Inst Biociencias, BR-18618970 Botucatu, SP, Brazil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Instituto de Biociências, Departamento de Química
dc.descriptionFAPESP: 2010/07639-9
dc.descriptionScience Without Borders Program: 246604/2012-3
dc.format80-85
dc.languageeng
dc.publisherElsevier B.V.
dc.relationMaterials Science &engineering C-materials For Biological Applications
dc.relation5.080
dc.relation1,110
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAlternate current biosusceptometry
dc.subjectGastric emptying
dc.subjectBio-magnetic materials
dc.subjectMuco-adhesive gel
dc.subjectCellulose
dc.subjectDextrose
dc.titleEnhancing the versatility of alternate current biosusceptometry (ACB) through the synthesis of a dextrose-modified tracer and a magnetic muco-adhesive cellulose gel
dc.typeArtigo


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