| dc.contributor | Universidade Estadual Paulista (Unesp) | |
| dc.creator | Ribeiro, Carlos Alberto S. [UNESP] | |
| dc.creator | Pupo, André S. [UNESP] | |
| dc.date | 2015-10-21T13:11:03Z | |
| dc.date | 2015-10-21T13:11:03Z | |
| dc.date | 2015-03-05 | |
| dc.date.accessioned | 2023-09-12T06:36:48Z | |
| dc.date.available | 2023-09-12T06:36:48Z | |
| dc.identifier | http://www.sciencedirect.com/science/article/pii/S0014299915000321 | |
| dc.identifier | European Journal Of Pharmacology. Amsterdam: Elsevier Science Bv, v. 750, p. 39-42, 2015. | |
| dc.identifier | 0014-2999 | |
| dc.identifier | http://hdl.handle.net/11449/128566 | |
| dc.identifier | 10.1016/j.ejphar.2015.01.010 | |
| dc.identifier | WOS:000350389200007 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8777916 | |
| dc.description | Imipramine is a tricyclic antidepressant inhibitor of norepinephrine and serotonin neuronal reuptake. The roles of specific alpha(1)-adrenoceptor subtypes that might be targeted by the increased synaptic levels of noradrenaline induced by imipramine are not well understood. This study investigates the alpha(1)-adrenoceptor subtypes involved in the anti-immobility effect of imipramine in the mouse tail suspension test. The antiimmobility effect of imipramine (32 mg/kg, i.p.) was significantly antagonised by the non-subtype-selective alpha(1)-adrenoceptor antagonist prazosin (0.5 and 1.0 mg/kg, i.p.). Neither the selective alpha(1A)-adrenoceptor antagonist 5-methyl-3-[3-[3-[4-[2-(2,2,2,-trifluroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidineclione (RS-100329, 0.5 and 1.0 mg/kg) nor the selective alpha(1D)-adrenoceptor antagonist 8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride, (BMY-7378, up to 1.0 mg/kg, i.p.) affected the anti-immobility effect of imipramine. However, the anti-immobility effect of imipramine was significantly antagonised by the selective alpha(1B)-adrenoceptor antagonist (2S)-4-(4-amino-6,7-dimethoxy-2quinazoliny1)-2-[[(1,1-dimethylethyl)aminolcarbonyl]-1-piperazinecarboxylate (L-765,314). In addition, mice treated only with RS-100329 or BMY-7378, but not with L-765,314, showed reduced immobility times in comparison to mice treated with vehicle. These results indicate that the selective antagonism of alpha(1A)- and alpha(1D)- adrenoceptors results in antidepressant-like effects and that the am-subtype is the main target for the increased levels of noradrenaline caused by imipramine. (C) 2015 Elsevier B.V. All rights reserved. | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Department of Pharmacology, Instituto de Biociências, UNESP, Botucatu, SP, Brazil | |
| dc.description | FAPESP: 08/50423-7 | |
| dc.format | 39-42 | |
| dc.language | eng | |
| dc.publisher | Elsevier B.V. | |
| dc.relation | European Journal Of Pharmacology | |
| dc.relation | 3.040 | |
| dc.relation | 1,057 | |
| dc.rights | Acesso restrito | |
| dc.source | Web of Science | |
| dc.subject | Alpha(1)-Adrenoceptors | |
| dc.subject | Alpha(1B)-Adrenoceptor | |
| dc.subject | Tricyclic antidepressants | |
| dc.subject | Imipramine | |
| dc.subject | Tail suspension test | |
| dc.title | Involvement of alpha(1B)-adrenoceptors in the anti-immobility effect of imipramine in the tail suspension test | |
| dc.type | Artigo | |
