Peritoneal dialysis per se is a risk factor for sclerostin-associated adynamic bone disease

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Federal do Rio Grande do Norte (UFRN)
dc.contributorPontificia Universidade Católica Paraná (PUC-PR)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.contributorUniversidade Nove de Julho (UNINOVE)
dc.creatorOliveira, Rodrigo A. de
dc.creatorBarreto, Fellype C.
dc.creatorMendes, Monique
dc.creatorReis, Luciene M. dos
dc.creatorCastro, Joao Henrique [UNESP]
dc.creatorBritto, Zita Maria L.
dc.creatorMarques, Igor D. B.
dc.creatorCarvalho, Aluizio B.
dc.creatorMoyses, Rosa M.
dc.creatorJorgetti, Vanda
dc.date2015-10-21T13:08:52Z
dc.date2015-10-21T13:08:52Z
dc.date2015-05-01
dc.date.accessioned2023-09-12T06:32:10Z
dc.date.available2023-09-12T06:32:10Z
dc.identifierhttp://www.nature.com/ki/journal/v87/n5/full/ki2014372a.html
dc.identifierKidney International, v. 87, n. 5, p. 1039-1045, 2015.
dc.identifier0085-2538
dc.identifierhttp://hdl.handle.net/11449/128307
dc.identifier10.1038/ki.2014.372
dc.identifierWOS:000354066900021
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8777659
dc.descriptionChronic kidney disease-mineral bone disorder (CKD-MBD) is a complex syndrome influenced by various factors, such as age, CKD etiology, uremic toxins, and dialysis modality. Although extensively studied in hemodialysis (HD) patients, only a few studies exist for peritoneal dialysis (PD) patients. Since most of these older studies contain no bone biopsy data, we studied the pattern of renal osteodystrophy in 41 prevalent PD patients. The most common presentation was adynamic bone disease (49%). There was a significant inverse association between serum sclerostin (a Wnt/beta-catenin pathway inhibitor that decreases osteoblast action and bone formation) and the bone formation rate. Bone alkaline phosphatase had the best sensitivity and specificity to detect both high-and low-turnover diseases. The comparison between nondiabetic PD and HD patients, matched by age, gender, parathyroid hormone level, and length of dialysis, revealed low 25-hydroxyvitamin D levels, worse bone mineralization, and low bone turnover in the nondiabetic PD group. Thus, adynamic bone disease was the most frequent type of renal osteodystrophy in PD patients. Sclerostin seems to participate in the pathophysiology of adynamic bone disease and bone alkaline phosphatase was the best serum marker of bone turnover in these patients.
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionUniv Sao Paulo, Dept Internal Med, Div Nephrol, BR-01246903 Sao Paulo, Brazil
dc.descriptionUniv Fed Rio Grande do Norte, Dept Integrated Med, BR-59072970 Natal, RN, Brazil
dc.descriptionPontificia Univ Catolica Parana, Sch Med, Curitiba, Parana, Brazil
dc.descriptionUniv Estadual Paulista, Dept Internal Med, Div Nephrol, Botucatu, SP, Brazil
dc.descriptionUniv Fed Sao Paulo, Dept Internal Med, Div Nephrol, Sao Paulo, Brazil
dc.descriptionUniv Nove de Julho UNINOVE, Med Master Degree Program, Sao Paulo, Brazil
dc.descriptionUniv Estadual Paulista, Dept Internal Med, Div Nephrol, Botucatu, SP, Brazil
dc.descriptionCNPq: 304249/2013-0
dc.descriptionCNPq: 304773/2013-1
dc.descriptionFAPESP: 2010/06117-9
dc.format1039-1045
dc.languageeng
dc.publisherNature Publishing Group
dc.relationKidney International
dc.relation8.429
dc.relation3,238
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectChronic kidney disease
dc.subjectDiabetes
dc.subjectMineral metabolism
dc.subjectPeritoneal dialysis
dc.subjectVascular calcification
dc.titlePeritoneal dialysis per se is a risk factor for sclerostin-associated adynamic bone disease
dc.typeArtigo


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