Candida species biofilm and Candida albicans ALS3 polymorphisms in clinical isolates

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorBruder-nascimento, Ariane [UNESP]
dc.creatorCamargo, Carlos Henrique [UNESP]
dc.creatorMondelli, Alessandro Lia [UNESP]
dc.creatorSugizaki, Maria Fátima [UNESP]
dc.creatorSadatsune, Terue [UNESP]
dc.creatorBagagli, Eduardo [UNESP]
dc.date2015-08-26T19:19:16Z
dc.date2015-08-26T19:19:16Z
dc.date2014-12-01
dc.date.accessioned2023-09-12T06:15:03Z
dc.date.available2023-09-12T06:15:03Z
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000400030&lng=en&nrm=iso&tlng=en
dc.identifierBrazilian Journal of Microbiology, v. 45, n. 4, p. 1371-1377, 2014.
dc.identifier1517-8382
dc.identifierhttp://hdl.handle.net/11449/127347
dc.identifier10.1590/S1517-83822014000400030
dc.identifierS1517-83822014000400030
dc.identifierS1517-83822014000400030.pdf
dc.identifier3320327570429539
dc.identifier0000-0002-8003-4109
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8776709
dc.descriptionOver the last decades, there have been important changes in the epidemiology of Candida infections. In recent years, Candida species have emerged as important causes of invasive infections mainly among immunocompromised patients. This study analyzed Candida spp. isolates and compared the frequency and biofilm production of different species among the different sources of isolation: blood, urine, vulvovaginal secretions and peritoneal dialysis fluid. Biofilm production was quantified in 327 Candida isolates obtained from patients attended at a Brazilian tertiary public hospital (Botucatu, Sao Paulo). C. albicans ALS3 gene polymorphism was also evaluated by determining the number of repeated motifs in the central domain. Of the 198 total biofilm-positive isolates, 72 and 126 were considered as low and high biofilm producers, respectively. Biofilm production by C. albicans was significantly lower than that by non-albicans isolates and was most frequently observed in C. tropicalis. Biofilm production was more frequent among bloodstream isolates than other clinical sources,in urine, the isolates displayed a peculiar distribution by presenting two distinct peaks, one containing biofilm-negative isolates and the other containing isolates with intense biofilm production. The numbers of tandem-repeat copies per allele were not associated with biofilm production, suggesting the evolvement of other genetic determinants.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho Instituto de Biociências de Botucatu
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de Botucatu
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho Instituto de Biociências de Botucatu
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de Botucatu
dc.descriptionFAPESP: 2007/01946-4
dc.descriptionFAPESP: 2008/10835-4
dc.descriptionFAPESP: 2008/09231-7
dc.format1371-1377
dc.languageeng
dc.publisherSociedade Brasileira de Microbiologia
dc.relationBrazilian Journal of Microbiology
dc.relation1.810
dc.relation0,630
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subjectCandida spp.
dc.subjectBiofilm
dc.subjectALS3 gene
dc.titleCandida species biofilm and Candida albicans ALS3 polymorphisms in clinical isolates
dc.typeArtigo


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