MODULATION OF PARASITEMIA AND ANTIBODY-RESPONSE TO TRYPANOSOMA-CRUZI BY CYCLOPHOSPHAMIDE IN CALOMYS-CALLOSUS (RODENTIA, CRICETIDAE)

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBorges, M. M.
dc.creatorCuri, P. R.
dc.creatorKloetzel, J. K.
dc.date2014-05-20T15:22:30Z
dc.date2016-10-25T17:56:12Z
dc.date2014-05-20T15:22:30Z
dc.date2016-10-25T17:56:12Z
dc.date1992-01-01
dc.date.accessioned2017-04-05T23:37:01Z
dc.date.available2017-04-05T23:37:01Z
dc.identifierRevista do Instituto de Medicina Tropical de São Paulo. São Paulo: Inst Medicina Tropical, v. 34, n. 1, p. 1-8, 1992.
dc.identifier0036-4665
dc.identifierhttp://hdl.handle.net/11449/33467
dc.identifierhttp://acervodigital.unesp.br/handle/11449/33467
dc.identifierWOS:A1992HU08200001
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/1307406
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/877580
dc.descriptionCalomys callosus a wild rodent, previously described as harboring Trypanosoma cruzi, has a low susceptibility to infection by this protozoan.Experiments were designed to evaluate the contribution of the immune response to the resistance to T. cruzi infection exhibited by C. callosus. Animals were submitted to injections of high (200 mg/kg body weight) and low (20 mg/kg body weight) doses of cyclophosphamide on days -1 or -1 and +5, and inoculated with 4 x 10(3) T. cruzi on day O. Parasitemia, mortality and antibody response as measured by direct agglutination of trypomastigotes were observed. Two hundred mg doses of cyclophosphamide resulted in higher parasitemia and mortality as well as in suppression of the antibody response. A single dose of 20 mg enhanced antibody levels on the 20th day after infection, while an additional dose did not further increase antibody production. Parasitemia levels were not depressed, but rather increased in both these groups as compared to untreated controls. Passive transfer of hyperimmune C. callosus anti-T. cruzi serum to cyclophosphamide immunosuppressed animals resulted in lower parasitemia and mortality rates. These results indicate that the immune response plays an important role in the resistance of C. callosus to T. cruzi.
dc.languageeng
dc.publisherInst Medicina Tropical
dc.relationRevista do Instituto de Medicina Tropical de São Paulo
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCALOMYS-CALLOSUS
dc.subjectCYCLOPHOSPHAMIDE
dc.subjectTRYPANOSOMA-CRUZI
dc.subjectPARASITEMIA
dc.subjectMORTALITY
dc.subjectANTIBODY RESPONSE
dc.titleMODULATION OF PARASITEMIA AND ANTIBODY-RESPONSE TO TRYPANOSOMA-CRUZI BY CYCLOPHOSPHAMIDE IN CALOMYS-CALLOSUS (RODENTIA, CRICETIDAE)
dc.typeOtro


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