CRF1 and CRF2 receptors in the bed nucleus of the stria terminalis modulate the cardiovascular responses to acute restraint stress in rats

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de São Carlos (UFSCAR)
dc.creatorOliveira, Leandro A. [UNESP]
dc.creatorAlmeida, Jeferson [UNESP]
dc.creatorBenini, Ricardo [UNESP]
dc.creatorCrestani, Carlos Cesar [UNESP]
dc.date2015-08-06T16:13:51Z
dc.date2015-08-06T16:13:51Z
dc.date2015
dc.date.accessioned2023-09-12T05:52:01Z
dc.date.available2023-09-12T05:52:01Z
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S1043661815000511
dc.identifierPharmacological Research, v. 95-96, p. 53-62, 2015.
dc.identifier1043-6618
dc.identifierhttp://hdl.handle.net/11449/126065
dc.identifier10.1016/j.phrs.2015.03.012
dc.identifier1117432571971568
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8775454
dc.descriptionThe corticotropin-releasing factor (CRF) is involved in behavioral and physiological responses to emotional stress throughits actioninseverallimbic structures,including the bednucleus ofthe stria terminalis (BNST). Nevertheless, the role of CRF1 and CRF2 receptors in the BNST in cardiovascular adjustments during aversive threat is unknown. Therefore, in the present study we investigated the involvement of CRF receptors within the BNST in cardiovascular responses evoked by acute restraint stress in rats. For this, we evaluated the effects of bilateral treatment of the BNST with selective agonists and antagonists of either CRF1 or CRF2 receptors in the arterial pressure and heart rate increase and the decrease in tail skin temperature induced by restraint stress. Microinjection of the selective CRF1 receptor antagonist CP376395 into the BNST reduced the pressor and tachycardiac responses caused by restraint. Conversely, BNST treatment with the selective CRF1 receptor agonist CRF increased restraint-evoked arterial pressure and HR responses and reduced the fall in tail skin temperature response. All effects of CRF were inhibited by local BNST pretreatment with CP376395. The selective CRF2 receptor antagonist antisalvagine-30 reduced the arterial pressure increase and the fall in tail skin temperature. The selective CRF2 receptor agonist urocortin-3 increased restraint-evoked pressor and tachycardiac responses and reduced the drop in cutaneous temperature. All effects of urocortin-3 were abolished by local BNST pretreatment with antisalvagine-30. These findings indicate an involvement of both CRF1 and CRF2 receptors in the BNST in cardiovascular adjustments during emotional stress.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Princípios Ativos Naturais e Toxicologia, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jau Km 01, Campus Universitário, CEP 14801902, SP, Brasil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Princípios Ativos Naturais e Toxicologia, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara-Jau Km 01, Campus Universitário, CEP 14801902, SP, Brasil
dc.descriptionFAPESP: 2012/14376-0
dc.descriptionFAPESP: 2012/50549-6
dc.format53-62
dc.languageeng
dc.relationPharmacological Research
dc.relation4.897
dc.relation1,811
dc.rightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectAutonomic activity
dc.subjectBed nucleus stria terminalis (BSNT)
dc.subjectCorticotropin releasing factor receptors
dc.subjectEmotional stress
dc.subjectExtended amygdala
dc.subjectNeuropeptides
dc.subjectUrocortin
dc.titleCRF1 and CRF2 receptors in the bed nucleus of the stria terminalis modulate the cardiovascular responses to acute restraint stress in rats
dc.typeArtigo


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