Short-term sustained hypoxia induces changes in the coupling of sympathetic and respiratory activities in rats

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorMoraes, Davi José de Almeida
dc.creatorBonagamba, Leni Gomes Heck
dc.creatorCosta, Kauê Machado
dc.creatorCosta-Silva, João Henrique
dc.creatorZoccal, Daniel Breseghello [UNESP]
dc.creatorMachado, Benedito Honório
dc.date2015-08-06T16:12:53Z
dc.date2015-08-06T16:12:53Z
dc.date2014
dc.date.accessioned2023-09-12T05:45:52Z
dc.date.available2023-09-12T05:45:52Z
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2013.262212/abstract?systemMessage=Wiley+Online+Library+will+have+intermittent+access+on+8th+August+2015+from+10%3A00-16%3A00+BST+%2F+05%3A00-11%3A00+EDT+%2F+17%3A00-23%3A00+SGT+for+essential+maintenance.++Apologies+for+the+inconvenience.
dc.identifierJournal of Physiology, v. 592, n. 9, p. 2013-2033, 2014.
dc.identifier0022-3751
dc.identifierhttp://hdl.handle.net/11449/125705
dc.identifier10.1113/jphysiol.2013.262212
dc.identifierISSN0022-3751-2014-592-09-2013-2033.pdf
dc.identifier1912911113942497
dc.identifier0617516188553954
dc.identifier1958567557189244
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8775104
dc.descriptionIndividuals experiencing sustained hypoxia (SH) exhibit adjustments in the respiratory and autonomic functions by neural mechanisms not yet elucidated. In the present study we evaluated the central mechanisms underpinning the SH-induced changes in the respiratory pattern and their impact on the sympathetic outflow. Using a decerebrated arterially perfused in situ preparation, we verified that juvenile rats exposed to SH (10% O2) for 24 h presented an active expiratory pattern, with increased abdominal, hypoglossal and vagal activities during late-expiration (late-E). SH also enhanced the activity of augmenting-expiratory neurones and depressed the activity of post-inspiratory neurones of the Botzinger complex (B ¨ otC) ¨ by mechanisms not related to changes in their intrinsic electrophysiological properties. SH rats exhibited high thoracic sympathetic activity and arterial pressure levels associated with an augmented firing frequency of pre-sympathetic neurones of the rostral ventrolateral medulla (RVLM) during the late-E phase. The antagonism of ionotropic glutamatergic receptors in the BotC/RVLM abolished the late-E bursts in expiratory and sympathetic outputs of SH rats, ¨ indicating that glutamatergic inputs to the BotC/RVLM are essential for the changes in the ¨ expiratory and sympathetic coupling observed in SH rats. We also observed that the usually silent late-E neurones of the retrotrapezoid nucleus/parafacial respiratory group became active in SH rats, suggesting that this neuronal population may provide the excitatory drive essential to the emergence of active expiration and sympathetic overactivity. We conclude that short-term SH induces the activation of medullary expiratory neurones, which affects the pattern of expiratory motor activity and its coupling with sympathetic activity.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionUniversidade de São Paulo, Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fisiologia e Patologia, Faculdade de Odontologia de Araraquara
dc.descriptionFAPESP: 2006/51159-6
dc.descriptionFAPESP: 2009/50113-0
dc.descriptionCNPq: 502098/2008-2
dc.descriptionCNPq: 301147/2008-6
dc.format2013-2033
dc.languageeng
dc.relationJournal of Physiology
dc.relation4.540
dc.relation2,051
dc.rightsAcesso aberto
dc.sourceCurrículo Lattes
dc.titleShort-term sustained hypoxia induces changes in the coupling of sympathetic and respiratory activities in rats
dc.typeArtigo


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