Ventricular remodeling and diastolic myocardial dysfunction in rats submitted to protein-calorie malnutrition

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFioretto, JR
dc.creatorQuerioz, S. S.
dc.creatorPadovani, Carlos Roberto
dc.creatorMatsubara, Luiz Shiguero
dc.creatorOkoshi, Katashi
dc.creatorMatsubara, Beatriz Bojikian
dc.date2014-05-20T15:22:18Z
dc.date2016-10-25T17:55:58Z
dc.date2014-05-20T15:22:18Z
dc.date2016-10-25T17:55:58Z
dc.date2002-04-01
dc.date.accessioned2017-04-05T23:35:56Z
dc.date.available2017-04-05T23:35:56Z
dc.identifierAmerican Journal of Physiology-heart and Circulatory Physiology. Bethesda: Amer Physiological Soc, v. 282, n. 4, p. H1327-H1333, 2002.
dc.identifier0363-6135
dc.identifierhttp://hdl.handle.net/11449/33309
dc.identifierhttp://acervodigital.unesp.br/handle/11449/33309
dc.identifier10.1152/ajpheart.00431.2001
dc.identifierWOS:000174365800020
dc.identifierhttp://ajpheart.physiology.org/content/282/4/H1327
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/877447
dc.descriptionThe effects of protein-calorie malnutrition (PCM) on heart structure and function are not completely understood. We studied heart morphometric, functional, and biochemical characteristics in undernourished young Wistar rats. They were submitted to PCM from birth (undernourished group, UG). After 10 wk, left ventricle function was studied using a Langendorff preparation. The results were compared with age-matched rats fed ad libitum (control group, CG). The UG rats achieved 47% of the body weight and 44% of the left ventricular weight (LVW) of the CG. LVW-to-ventricular volume ratio was smaller and myocardial hydroxyproline concentration was higher in the UG. Left ventricular systolic function was not affected by the PCM protocol. The myocardial stiffness constant was greater in the UG, whereas the end-diastolic pressure-volume relationship was not altered. In conclusion, the heart is not spared from the adverse effects of PCM. There is a geometric alteration in the left ventricle with preserved ventricular compliance despite the increased passive myocardial stiffness. The systolic function is preserved.
dc.languageeng
dc.publisherAmer Physiological Soc
dc.relationAmerican Journal of Physiology-heart and Circulatory Physiology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectleft ventricular function
dc.subjectLangendorff preparation
dc.subjectisolated heart
dc.titleVentricular remodeling and diastolic myocardial dysfunction in rats submitted to protein-calorie malnutrition
dc.typeOtro


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