Ibotenate lesion of the medial hypothalamus alters the salt intake and pressor responses to activation of the median preoptic nucleus in rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatordoVale, C. F.
dc.creatorCamargo, GMPA
dc.creatorRenzi, Antonio
dc.creatorLuiz, A. C.
dc.creatorSaad, W. A.
dc.creatorHetem, S.
dc.creatorCamargo, LAA
dc.date2014-05-20T15:22:09Z
dc.date2016-10-25T17:55:48Z
dc.date2014-05-20T15:22:09Z
dc.date2016-10-25T17:55:48Z
dc.date1997-02-01
dc.date.accessioned2017-04-05T23:35:17Z
dc.date.available2017-04-05T23:35:17Z
dc.identifierJournal of Physiology-paris. Paris: Editions Scientifiques Medicales Elsevier, v. 91, n. 1, p. 31-37, 1997.
dc.identifier0928-4257
dc.identifierhttp://hdl.handle.net/11449/33196
dc.identifierhttp://acervodigital.unesp.br/handle/11449/33196
dc.identifier10.1016/S0928-4257(99)80163-6
dc.identifierWOS:A1997XB08900004
dc.identifierhttp://dx.doi.org/10.1016/S0928-4257(99)80163-6
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/877367
dc.descriptionWe investigated the influence of ibotenic acid lesions of the medial hypothalamus (MH) on salt appetite and arterial blood pressure responses induced by angiotensinergic and adrenergic stimulation of the median preoptic nucleus (MnPO) of rats. Previous injection of the adrenergic agonists norepinephrine, clonidine, phenylephrine, and isoproterenol into the MnPO of sham MH-lesioned rats caused no change in the sodium intake induced by ANG II. ANG II injected into the MnPO of MH-lesioned rats increased sodium intake compared with sham-lesioned rats. Previous injection of clonidine and isoproterenol increased, whereas phenylephrine abolished the salt intake induced by ANG II into the MnPO of MH-lesioned rats. Previous injection of norepinephrine and clonidine into the MnPO of sham MH-lesioned rats caused no change in the mean arterial pressure (MAP) induced by ANG II. Under the same conditions, previous injection of phenylephrine increased, whereas isoproterenol reversed the increase in MAP induced by angiotensin II (ANG II). ANG II injected into the MnPO of MH-lesioned rats induce a decrease in MAP compared with sham-lesioned rats. Previous injection of phenylephrine or norepinephrine into the MnPO of MH-lesioned rats induced a negative MAP, whereas pretreatment with clonidine or isoproterenol increased the MAP produced by ANG II injected into the MnPO of sham- or MH-lesioned rats. These data show that ibotenic acid lesion of the MH increases the sodium intake and presser responses induced by the concomitant angiotensinergic, alpha(2) and beta adrenergic activation of the MnPO, whereas alpha(1) activation may have opposite effects. MH involvement in excitatory and inhibitory mechanisms related to sodium intake and MAP control is suggested.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationJournal of Physiology-paris
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectadrenergic agonists
dc.subjectmedial hypothalamus
dc.subjectangiotensin II
dc.subjectarterial pressure
dc.subjectsalt intake
dc.titleIbotenate lesion of the medial hypothalamus alters the salt intake and pressor responses to activation of the median preoptic nucleus in rats
dc.typeOtro


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