Atenolol characterization in solid formulations available in Brazilian market

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorSalvi, S. T. B.
dc.creatorAntonio, S. G.
dc.creatorSantos, Carlos de Oliveira Paiva [UNESP]
dc.date2015-05-15T13:30:18Z
dc.date2015-05-15T13:30:18Z
dc.date2013
dc.date.accessioned2023-09-12T05:02:09Z
dc.date.available2023-09-12T05:02:09Z
dc.identifierPowder Diffraction, v. 28, n. S2, p. S448-S457, 2013.
dc.identifier1945-7413
dc.identifierhttp://hdl.handle.net/11449/123498
dc.identifier10.1017/S0885715613000845
dc.identifier6963447973536648
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8772936
dc.descriptionAtenolol is the most used drug in Brazil to hypertension treatment. Two crystal structures are known for this molecule: a racemic form (R,S)-atenolol and a pure form S-atenolol. The racemic form is found in commercial tablets. X-ray powder diffraction (XRD) is an adequate tool to study crystalline structures including drugs. Using the Rietveld Method with XRD data it is possible to quantify the crystalline structures existing in the raw material. Other methods like Le Bail and Pawley can be used to the profile fit and phases identification. For this work we analyzed three tablets of atenolol, two generics and the reference (materials were purchased from a drugstore at the city of Araraquara). These tablets were analyzed by Rietveld, Le Bail and Pawley methods. All tablets exhibited the racemic mixture API (R,S)-atenolol. Some crystalline excipients could be characterized: magnesium carbonate hydrate, lactose monohydrate and talc. The conclusion is that the three methods can be efficiently used to characterize the three atenolol tablets.
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Físico-Química, Instituto de Química de Araraquara, Araraquara, R. Prof. Francisco Degni 55, Quitandinha, CEP 14800-060, SP, Brasil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Físico-Química, Instituto de Química de Araraquara, Araraquara, R. Prof. Francisco Degni 55, Quitandinha, CEP 14800-060, SP, Brasil
dc.formatS448-S457
dc.languageeng
dc.relationPowder Diffraction
dc.rightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectAtenolol
dc.subjectRietveld method
dc.subjectLe Bail method
dc.subjectPawley method
dc.subjectPharmaceutical
dc.subjectX-ray powder diffraction
dc.titleAtenolol characterization in solid formulations available in Brazilian market
dc.typeArtigo


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