Salivary and serum proteomics in head and neck carcinomas before and after surgery and radiotherapy

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorVidotto, A
dc.creatorHenrique, Tiago
dc.creatorRaposo, Luiz Sergio
dc.creatorManiglia, José Victor
dc.creatorSilva, Eloiza Helena Tajara da [UNESP]
dc.date2015-04-27T11:56:08Z
dc.date2015-04-27T11:56:08Z
dc.date2011
dc.date.accessioned2023-09-12T04:48:57Z
dc.date.available2023-09-12T04:48:57Z
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21896997
dc.identifierDisease Markers, v. 8, p. 95-107, 2011.
dc.identifier0278-0240
dc.identifierhttp://hdl.handle.net/11449/122916
dc.identifier9108148386775557
dc.identifier9164050774559761
dc.identifier4616314645396927
dc.identifier8102755896732025
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8772358
dc.descriptionSeveral body fluids have been evaluated as new sources for cancer biomarker discovery. In this context, salivary and serum proteomics seem promising diagnostic and predictive tools for head and neck diseases. In the present study, we performed a proteomic analysis of saliva and serum from patients presenting head and neck squamous cell carcinoma (HNSCC) and compared the results before and after therapy. In saliva of cancer patients, we observed an altered protein profile, including over-expression of PLUNC and zinc-alpha-2-glycoprotein. Both proteins may contribute to control tumor growth and, therefore, represent targets for new analysis. We also detected serotransferrin and a modified transthyretin form with altered levels in serum from patients. Comparing preoperative and postreatment samples, the results showed that the protein profile after treatment reverted to a pattern closer to those observed for controls. These results add information on the role of secreted proteins in the cancer process and emphasize the potential of saliva and serum analysis for diagnosis and monitoring of HNSCC.
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Instituto de Biociencias, Letras e Ciencias Exatas de Sao Jose do Rio Preto, Sao Jose do Rio Preto, RUA CRISTOVAO COLOMBO 2265 - DEPARTAMENTO DE MATEMATICA, JARDIM NAZARETH, CEP 15054-000, SP, Brasil
dc.format95-107
dc.languageeng
dc.relationDisease Markers
dc.relation2.949
dc.relation0,900
dc.rightsAcesso restrito
dc.sourceCurrículo Lattes
dc.titleSalivary and serum proteomics in head and neck carcinomas before and after surgery and radiotherapy
dc.typeArtigo


Este ítem pertenece a la siguiente institución