The mean corpuscular volume and hydroxyurea in brazilian patients with sickle cell anemia: a surrogate marker of compliance

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorQueiroz, Ana Maria Mach
dc.creatorLobo, Clarisse Lopes de Castro
dc.creatorNascimento, Emilia Matos do
dc.creatorPereira, Basilio de Bragança
dc.creatorBonini-Domingos, Claudia Regina [UNESP]
dc.creatorCardoso, Gilberto Perez
dc.creatorBallas, Samir K.
dc.date2015-04-27T11:55:52Z
dc.date2015-04-27T11:55:52Z
dc.date2013
dc.date.accessioned2023-09-12T04:42:08Z
dc.date.available2023-09-12T04:42:08Z
dc.identifierhttp://omicsonline.org/the-mean-corpuscular-volume-and-hydroxyurea-in-brazilian-patients-with-sickle-cell-anemia-a-surrogate-marker-of-compliance-2155-9864.1000157.php?aid=19934
dc.identifierJournal of Blood Disorders & Transfusion, v. 4, n. 5, p. 1-4, 2013.
dc.identifier2155-9864
dc.identifierhttp://hdl.handle.net/11449/122582
dc.identifier10.4172/2155-9864.1000157
dc.identifierISSN2155-9864-2013-04-05-01-04.pdf
dc.identifier3279428066176719
dc.identifier0000-0002-4603-9467
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8772032
dc.descriptionThe suppression of erythropoiesis by Hydroxyurea (HU) therapy is associated with increase in mean corpuscular volume, in addition to the increase in Hb F. Monitoring the mean corpuscular volume values and the presence of macrocytosis are effective tools of adherence to the treatment with HU in patients with sickle cell anemia. The aim of this study is to monitor the mean corpuscular volume values after starting treatment with HU to determine if macrocytosis can be used as a surrogate marker of compliance with therapy. We conducted a prospective cohort study over one year with measurements of blood counts and mean corpuscular volume after starting therapy with HU in 95 patients with sickle cell anemia who were regularly followed in our ambulatory outpatient unit. In one-year of successful use of HU the mean value of the mean corpuscular volume increased significantly. The Andersen and Gill model demonstrated that the increase of one unit of MCV implies a 5% reduction in the risk of visiting the emergency room. Monitoring mean corpuscular volume values after prescribing HU alerts the provider of noncompliance in order to counsel the patient in question for better adherence to the use of HU that could improve the quality of care and to reduce morbidity and the frequency of acute pain crises and associated healthcare costs.
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, Sao Jose do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054-000, SP, Brasil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, Sao Jose do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054-000, SP, Brasil
dc.descriptionHEMORIO-State Institute of Hematology Arthur de Siqueira Cavalcanti, Rio de Janeiro, Brazil
dc.descriptionFederal University of Rio de Janeiro, COPPE - Postgraduate School of Engineering, Rio de Janeiro, Brazil
dc.descriptionFederal University of Rio de Janeiro-School of Medicine, Rio de Janeiro, Brazil
dc.descriptionUNESP - Sao Paulo State University, Department of Biology, Hemoglobin and Hematologic Diseases Genetic Laboratory, São Paulo, Brazil
dc.descriptionUFF - Fluminense Federal University, Department of Clinical Medicine, School of Medicine, Niterói, Brazil
dc.descriptionCardeza Foundation, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA, USA
dc.format1-4
dc.languageeng
dc.relationJournal of Blood Disorders & Transfusion
dc.rightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectSickle cell anemia
dc.subjectHydroxyurea
dc.subjectCompliance
dc.subjectMean corpuscular volume
dc.titleThe mean corpuscular volume and hydroxyurea in brazilian patients with sickle cell anemia: a surrogate marker of compliance
dc.typeArtigo


Este ítem pertenece a la siguiente institución