Study of Salmonella typhimurium mutagenicity assay of (Z)-piplartine by the Ames test

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorDepartamento de Engenharia Química, Centro Universitário da FEI
dc.contributor4Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo (USP)
dc.creatorMorandim, Andréia de Araújo
dc.creatorCotinguiba, Fernando [UNESP]
dc.creatorRegasini, Luis Octavio [UNESP]
dc.creatorFrigieri, Mariana Carina [UNESP]
dc.creatorVaranda, Eliana Aparecida [UNESP]
dc.creatorCoqueiro, Aline [UNESP]
dc.creatorKato, Massuo Jorge
dc.creatorBolzani, Vanderlan da Silva [UNESP]
dc.creatorFurlan, Maysa [UNESP]
dc.date2015-04-27T11:55:45Z
dc.date2015-04-27T11:55:45Z
dc.date2011
dc.date.accessioned2023-09-12T04:39:00Z
dc.date.available2023-09-12T04:39:00Z
dc.identifierAfrican Journal of Biotechnology, v. 10, n. 27, p. 5398-5401, 2011.
dc.identifier1684-5315
dc.identifierhttp://hdl.handle.net/11449/122438
dc.identifier10.5897/AJB10.2576
dc.identifierISSN1684-5315-2011-10-27-5398-5401.pdf
dc.identifier7948388584717287
dc.identifier4484083685251673
dc.identifier0992736452764550
dc.identifier1308042794786872
dc.identifier7501930236496670
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8771889
dc.descriptionPhytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (E)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound.
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química e Ciências Ambientais, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054000, SP, Brasil
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química e Ciências Ambientais, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, CEP 15054000, SP, Brasil
dc.description1Departamento de Química Orgânica, Instituto de Química, Universidade Estadual de São Paulo, Rua Francisco Degni, s/n, 14800-900 Araraquara-SP, Brazil.
dc.descriptionDepartamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Rodovia Araraquara/Jaú Km 1, 14801-902 Araraquara-SP, Brazil.
dc.descriptionFAPESP
dc.descriptionCNPq
dc.format5398-5401
dc.languageeng
dc.relationAfrican Journal of Biotechnology
dc.rightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectPiperaceae
dc.subjectPiper tuberculatum
dc.subject(Z)-piplartine
dc.subjectmutagenic activated
dc.subjectAmes test.
dc.titleStudy of Salmonella typhimurium mutagenicity assay of (Z)-piplartine by the Ames test
dc.typeArtigo


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