Serotonergic mechanisms of the lateral parabrachial nucleus and cholinergic-induced sodium appetite

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMenani, José Vanderlei
dc.creatorBarbosa, S. P.
dc.creatorDe Luca, L. A.
dc.creatorDe Gobbi, JIF
dc.creatorJohnson, A. K.
dc.date2014-05-20T15:21:23Z
dc.date2016-10-25T17:54:48Z
dc.date2014-05-20T15:21:23Z
dc.date2016-10-25T17:54:48Z
dc.date2002-03-01
dc.date.accessioned2017-04-05T23:31:08Z
dc.date.available2017-04-05T23:31:08Z
dc.identifierAmerican Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 282, n. 3, p. R837-R841, 2002.
dc.identifier0363-6119
dc.identifierhttp://hdl.handle.net/11449/32542
dc.identifierhttp://acervodigital.unesp.br/handle/11449/32542
dc.identifierWOS:000173779200026
dc.identifierhttp://ajpregu.physiology.org/content/282/3/R837
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/876861
dc.descriptionCentral cholinergic mechanisms are suggested to participate in osmoreceptor-induced water intake. Therefore, central injections of the cholinergic agonist carbachol usually produce water intake (i.e., thirst) and are ineffective in inducing the intake of hypertonic saline solutions (i.e., the operational definition of sodium appetite). Recent studies have indicated that bilateral injections of the serotonin receptor antagonist methysergide into the lateral parabrachial nucleus (LPBN) markedly increases salt intake in models involving the activation of the renin-angiotensin system or mineralocorticoid hormones. The present studies investigated whether sodium appetite could be induced by central cholinergic activation with carbachol (an experimental condition where only water is typically ingested) after the blockade of LPBN serotonergic mechanisms with methysergide treatment in rats. When administered intracerebroventricularly in combination with injections of vehicle into both LPBN, carbachol (4 nmol) caused water drinking but insignificant intake of hypertonic saline. In contrast, after bilateral LPBN injections of methysergide (4 mug), intracerebroventricular carbachol induced the intake of 0.3 M NaCl. Water intake stimulated by intracerebroventricular carbachol was not changed by LPBN methysergide injections. The results indicate that central cholinergic activation can induce marked intake of hypertonic NaCl if the inhibitory serotonergic mechanisms of the LPBN are attenuated.
dc.languageeng
dc.publisherAmer Physiological Soc
dc.relationAmerican Journal of Physiology: Regulatory Integrative and Comparative Physiology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcarbachol
dc.subjectwater intake
dc.subjectthirst
dc.subjectsalt intake
dc.subjectsalt appetite
dc.subject5-hydroxytryptamine
dc.titleSerotonergic mechanisms of the lateral parabrachial nucleus and cholinergic-induced sodium appetite
dc.typeOtro


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