Single nucleotide polymorphisms in candidate genes associated with gastrointestinal nematode infection in goats

dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.contributorUniversidade Federal de São Carlos (UFSCar)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Federal de Lavras (UFLA)
dc.contributorUniv Fed Rio Grande do Norte
dc.contributorUniversidade de São Paulo (USP)
dc.creatorBressani, F. A.
dc.creatorTizioto, P. C.
dc.creatorGiglioti, R. [UNESP]
dc.creatorMeirelles, S. L. C.
dc.creatorCoutinho, R.
dc.creatorBenvenuti, C. L.
dc.creatorMalago-, W.
dc.creatorMudadu, M. A.
dc.creatorVieira, L. S.
dc.creatorZaros, L. G.
dc.creatorCarrilho, E.
dc.creatorRegitano, L. C. A.
dc.date2015-03-18T15:56:26Z
dc.date2015-03-18T15:56:26Z
dc.date2014-01-01
dc.date.accessioned2023-09-12T03:14:19Z
dc.date.available2023-09-12T03:14:19Z
dc.identifierhttp://dx.doi.org/10.4238/2014.October.20.29
dc.identifierGenetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 13, n. 4, p. 8530-8536, 2014.
dc.identifier1676-5680
dc.identifierhttp://hdl.handle.net/11449/117565
dc.identifier10.4238/2014.October.20.29
dc.identifierWOS:000345119800047
dc.identifierWOS000345119800047.pdf
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8767049
dc.descriptionCytokines are small cell-signaling proteins that play an important role in the immune system, participating in intracellular communication. Four candidate genes of the cytokine family (IL2, IL4, IL13, and IFNG) were selected to identify Single Nucleotide Polymorphisms (SNPs) that might be associated with resistance to gastrointestinal endoparasites in goats. A population of 229 goats, F2 offspring from an F1 intercross was produced by crossing pure Saanen goats, considered as susceptible to gastrointestinal endoparasites, with pure Anglo-Nubian goats, considered resistant. Blood was collected for DNA extraction and fecal samples were also collected for parasite egg count. Polymorphisms were prospected by sequencing animals with extreme phenotype for fecal egg count (FEC) distribution. The association between SNPs and phenotype was determined by using the Fisher exact test with correction for multiple tests. Three of the 10 SNPs were identified as significant (P <= 0.03). They were found in intron 1 of IL2 (ENSBTA00000020883), intron 3 of IL13 (ENSBTA00000015953) and exon 3 of IFNG (ENSBTA00000012529), suggesting an association between them and gastrointestinal endoparasite resistance. Further studies will help describe the effects of these markers accurately before implementing them in marker assisted selection. This study is the pioneer in describing such associations in goats.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionEmbrapa Pecuaria Sudeste, Sao Carlos, SP, Brazil
dc.descriptionUniv Fed Sao Carlos, Programa Posgrad Genet Evolut & Biol Mol, BR-13560 Sao Carlos, SP, Brazil
dc.descriptionUniv Estadual Paulista, Programa Posgrad Genet & Melhoramento Anim, Jaboticabal, SP, Brazil
dc.descriptionUniv Fed Lavras, Dept Zootecnia, Lavras, MG, Brazil
dc.descriptionUniv Fed Rio Grande do Norte, BR-59072970 Natal, RN, Brazil
dc.descriptionEmbrapa Caprinos & Ovinos, Sobral, CE, Brazil
dc.descriptionUniv Sao Paulo, Dept Quim, Sao Carlos, SP, Brazil
dc.descriptionUniv Estadual Paulista, Programa Posgrad Genet & Melhoramento Anim, Jaboticabal, SP, Brazil
dc.format8530-8536
dc.languageeng
dc.publisherFunpec-editora
dc.relationGenetics And Molecular Research
dc.relation0,439
dc.rightsAcesso aberto
dc.sourceWeb of Science
dc.subjectSingle nucleotide polymorphism
dc.subjectCapra hircus
dc.subjectCytokine
dc.subjectGastrointestinal infection
dc.titleSingle nucleotide polymorphisms in candidate genes associated with gastrointestinal nematode infection in goats
dc.typeArtigo


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