Animal models in chronic obstructive pulmonary disease-an overview

dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorMarcelino, Monica Yonashiro
dc.creatorFuoco, Natalia Langenfeld
dc.creatorFaria, Carolina Arruda de
dc.creatorKozma, Rodrigo de Las Heras
dc.creatorMarques, Lais Fernanda [UNESP]
dc.creatorRibeiro-Paes, Joao Tadeu [UNESP]
dc.date2015-03-18T15:56:19Z
dc.date2015-03-18T15:56:19Z
dc.date2014-08-01
dc.date.accessioned2023-09-12T03:12:47Z
dc.date.available2023-09-12T03:12:47Z
dc.identifierhttp://dx.doi.org/10.3109/01902148.2014.908250
dc.identifierExperimental Lung Research. London: Informa Healthcare, v. 40, n. 6, p. 259-271, 2014.
dc.identifier0190-2148
dc.identifierhttp://hdl.handle.net/11449/117479
dc.identifier10.3109/01902148.2014.908250
dc.identifierWOS:000339561600001
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8766963
dc.descriptionChronic obstructive pulmonary disease (COPD) is characterized by progressive airway obstruction resultant from an augmented inflammatory response of the respiratory tract to noxious particles and gases. Previous reports present a number of different hypotheses about the etiology and pathophysiology of COPD. The generating mechanisms of the disease are subject of much speculation, and a series of questions and controversies among experts still remain. In this context, several experimental models have been proposed in order to broaden the knowledge on the pathophysiological characteristics of the disease, as well as the search for new therapeutic approaches for acute or chronically injured lung tissue. This review aims to present the main experimental models of COPD, more specifically emphysema, as well as to describe the main characteristics, advantages, disadvantages, possibilities of application, and potential contribution of each of these models for the knowledge on the pathophysiological aspects and to test new treatment options for obstructive lung diseases.
dc.descriptionUniv Sao Paulo, Inst Butantan, Program Postgrad Biotechnol, Sao Paulo, Brazil
dc.descriptionUniv Sao Paulo Ribeirao Preto, Ribeirao Preto Med Sch, Dept Genet, Sao Paulo, Brazil
dc.descriptionUniv Estadual Paulista, Dept Biol Sci, Assis, SP, Brazil
dc.descriptionUniv Estadual Paulista, Dept Biol Sci, Assis, SP, Brazil
dc.format259-271
dc.languageeng
dc.publisherInforma Healthcare
dc.relationExperimental Lung Research
dc.relation1.878
dc.relation0,587
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectanimal model
dc.subjectchronic obstructive pulmonary disease
dc.subjectemphysema
dc.titleAnimal models in chronic obstructive pulmonary disease-an overview
dc.typeArtigo


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