Physical Exercise in MCI Elderly Promotes Reduction of Pro-Inflammatory Cytokines and Improvements on Cognition and BDNF Peripheral Levels

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.contributorUniv Vigo
dc.contributorUniversidade Federal de São Carlos (UFSCar)
dc.creatorNascimento, Carla Manuela Crispim [UNESP]
dc.creatorPereira, Jessica Rodrigues [UNESP]
dc.creatorAndrade, Larissa Pires de [UNESP]
dc.creatorGaruffi, Marcelo [UNESP]
dc.creatorTalib, Leda Leme
dc.creatorForlenza, Orestes Vicente
dc.creatorMaria Cancela, Jose
dc.creatorCominetti, Marcia Regina
dc.creatorStella, Florindo [UNESP]
dc.date2015-03-18T15:56:12Z
dc.date2015-03-18T15:56:12Z
dc.date2014-01-01
dc.date.accessioned2023-09-12T03:12:27Z
dc.date.available2023-09-12T03:12:27Z
dc.identifierhttp://dx.doi.org/10.2174/156720501108140910122849
dc.identifierCurrent Alzheimer Research. Sharjah: Bentham Science Publ Ltd, v. 11, n. 8, p. 799-805, 2014.
dc.identifier1567-2050
dc.identifierhttp://hdl.handle.net/11449/117458
dc.identifier10.2174/156720501108140910122849
dc.identifierWOS:000342142600009
dc.identifier7964386240653380
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8766942
dc.descriptionThe benefits of physical exercise to reduce low-grade inflammation and improve Brain-Derived Neurotrophic Factor (BDNF) levels and cognitive function became a growing field of interest. Low-grade inflammation is common during aging and seems to be linked to neurodegenerative process. Regular physical exercises can help to reduce pro-inflammatory cytokines levels and to improve BDNF peripheral concentrations. The main goal of this research was to analyze the effects of a 16-week multimodal physical exercise program on peripheral BDNF levels and on Tumor Necrosis-alpha (TNF-alpha) and Interleukin-6 (IL-6) as pro-inflammatory markers in cognitive healthy elderly individuals and in elderly with mild cognitive impairment (MCI). Cognitive functions were assessed by the Montreal Cognitive Assessment (MoCA) prior to and after the intervention. Thirty cognitively healthy participants and thirty-seven MCI participants were assigned to the control (CG) and trained (TG) groups. The TG participated in a multimodal physical training program for a 16-week period. The results showed a significant between-subjects interaction, which indicates the beneficial contribution of training on the reduction of TNF-alpha (p= 0.001) and IL-6 (p<0.001) and on the improvement of BDNF (p<0.001) peripheral concentrations. Cognitive functions also presented significant improvements for MCI trained group (p= 0.03). In conclusion, physical exercise was effective to reduce pro-inflammatory cytokines and to improve BDNF peripheral levels, with positive reflexes on cognition. To the best of our knowledge, this is the first study that evaluated longitudinally the effects of a multimodal physical exercises protocol on peripheral concentrations of pro-inflammatory cytokines and cognition performance in elderly MCI individuals.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionUNESP Univ Estadual Paulista, Dept Educ Fis, Lab Envelhecimento & Atividade Fis LAFE, BR-13506900 Rio Claro, SP, Brazil
dc.descriptionUniv Sao Paulo, Fac Med, Dept Psiquiatria, BR-01060970 Sao Paulo, Brazil
dc.descriptionUniv Sao Paulo, Fac Med, Inst Psiquiatria, Lab Neurociencias LIM 27, BR-01060970 Sao Paulo, Brazil
dc.descriptionUniv Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-01060970 Sao Paulo, Brazil
dc.descriptionUniv Vigo, HealthyFyt Grp, Fac Ciencias Deporte, Vigo 36310, Spain
dc.descriptionUniv Fed Sao Carlos, Dept Gerontol, Lab Biol Envelhecimento LABEN, BR-13565905 Sao Carlos, SP, Brazil
dc.descriptionUNESP Univ Estadual Paulista, Inst Biociencias, BR-13506900 Sao Paulo, Brazil
dc.descriptionUNESP Univ Estadual Paulista, Dept Educ Fis, Lab Envelhecimento & Atividade Fis LAFE, BR-13506900 Rio Claro, SP, Brazil
dc.descriptionUNESP Univ Estadual Paulista, Inst Biociencias, BR-13506900 Sao Paulo, Brazil
dc.descriptionFAPESP: 02/13633-7
dc.format799-805
dc.languageeng
dc.publisherBentham Science Publ Ltd
dc.relationCurrent Alzheimer Research
dc.relation3.289
dc.relation1,187
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAging
dc.subjectcognition
dc.subjectinflammation
dc.subjectinterleukin-6
dc.subjectmild cognitive impairment
dc.subjectphysical activity
dc.subjecttumor necrosis factor alpha
dc.titlePhysical Exercise in MCI Elderly Promotes Reduction of Pro-Inflammatory Cytokines and Improvements on Cognition and BDNF Peripheral Levels
dc.typeArtigo


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