Resistance training with excessive training load and insufficient recovery alters skeletal muscle mass-related protein expression

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorNorth Univ Parana UNOPAR
dc.contributorUniversidade Estadual de Campinas (UNICAMP)
dc.creatorAlves Souza, Rodrigo Wagner [UNESP]
dc.creatorAguiar, Andreo F. [UNESP]
dc.creatorVechetti-Junior, Ivan J. [UNESP]
dc.creatorPiedade, Warlen Pereira [UNESP]
dc.creatorRocha Campos, Gerson Eduardo
dc.creatorDal-Pai-Silva, Maeli [UNESP]
dc.date2015-03-18T15:56:07Z
dc.date2015-03-18T15:56:07Z
dc.date2014-08-01
dc.date.accessioned2023-09-12T03:11:54Z
dc.date.available2023-09-12T03:11:54Z
dc.identifierhttp://dx.doi.org/10.1519/JSC.0000000000000421
dc.identifierJournal Of Strength And Conditioning Research. Philadelphia: Lippincott Williams & Wilkins, v. 28, n. 8, p. 2338-2345, 2014.
dc.identifier1064-8011
dc.identifierhttp://hdl.handle.net/11449/117425
dc.identifier10.1519/JSC.0000000000000421
dc.identifierWOS:000340206400031
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8766909
dc.descriptionThe aim of this study was to investigate the effects of a resistance training program with excessive training load and insufficient recovery time between bouts on muscle hypertrophy-and atrophy-related protein expression. Male Wistar rats were randomly assigned to either a trained (TR, N = 9) or a sedentary (SE, N = 9) group. The TR group was subjected to a 12-week resistance training program with excessive training load and insufficient recovery between bouts that was designed to induce plantaris muscle atrophy. After the 12-week experiment, the plantaris muscle was collected to analyze the cross-sectional area (CSA) of the muscle fibers, and MAFbx, MyoD, myogenin, and IGF-I protein expression (Western blot). The CSA was reduced significantly (-17%, p <= 0.05) in the TR group compared with the SE group. Reciprocally, there was a significant (p <= 0.05) 20% increase in MAFbx protein expression, whereas the MyoD (-27%), myogenin (-29%), and IGF-I (-43%) protein levels decreased significantly (p <= 0.05) in the TR group compared with the SE group. In conclusion, our data indicated that muscle atrophy induced by resistance training with excessive training load and insufficient recovery was associated with upregulation of the MAFbx catabolic protein and downregulation of the MyoD, myogenin, and IGF-I anabolic proteins. These findings suggest that quantitative analysis of these proteins can be important and complementary with other biochemical markers to confirm a possible overtraining diagnosis.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionSao Paulo State Univ UNESP, Dept Morphol, Sao Paulo, Brazil
dc.descriptionNorth Univ Parana UNOPAR, Ctr Biol & Hlth Sci, Londrina, Parana, Brazil
dc.descriptionUniv Estadual Campinas, Dept Anat Cell Biol Physiol & Biophys, Sao Paulo, Brazil
dc.descriptionSao Paulo State Univ UNESP, Dept Morphol, Sao Paulo, Brazil
dc.descriptionFAPESP: 08/52641-1
dc.descriptionCNPq: 130628/2008-5
dc.format2338-2345
dc.languageeng
dc.publisherLippincott Williams & Wilkins
dc.relationJournal Of Strength And Conditioning Research
dc.relation2.325
dc.relation1,366
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectoverworked muscles
dc.subjectmuscle atrophy
dc.subjectMAFbx
dc.subjectMyoD
dc.subjectmyogenin
dc.subjectIGF-I
dc.titleResistance training with excessive training load and insufficient recovery alters skeletal muscle mass-related protein expression
dc.typeArtigo


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