First detection of Leishmania infantum DNA within the brain of naturally infected dogs

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniv Extremadura
dc.creatorGrano, Fernanda G. [UNESP]
dc.creatorMelo, Guilherme D. [UNESP]
dc.creatorBelinchon-Lorenzo, Silvia
dc.creatorGomez-Nieto, Luis C.
dc.creatorMachado, Gisele F. [UNESP]
dc.date2015-03-18T15:54:08Z
dc.date2015-03-18T15:54:08Z
dc.date2014-08-29
dc.date.accessioned2023-09-09T11:11:15Z
dc.date.available2023-09-09T11:11:15Z
dc.identifierhttp://dx.doi.org/10.1016/j.vetpar.2014.05.015
dc.identifierVeterinary Parasitology. Amsterdam: Elsevier Science Bv, v. 204, n. 3-4, p. 376-380, 2014.
dc.identifier0304-4017
dc.identifierhttp://hdl.handle.net/11449/116790
dc.identifier10.1016/j.vetpar.2014.05.015
dc.identifierWOS:000341472700042
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8766275
dc.descriptionVisceral leishmaniasis is an anthropozoonosis caused by the protozoan Leishmania infantum (L. chagasi). In dogs, the disease presents with systemic manifestations, including neurological disorders. There are rare reports of the presence of the parasite in the central nervous system of infected dogs, and some evidences of inflammatory lesions and the breakdown of cerebral barriers have been described. The aim of this study was to investigate the presence of L infantum DNA in five specific areas of the brains of 20 naturally infected dogs by real-time PCR. For the first time, the presence of parasite DNA was detected and quantified in the brains of naturally infected dogs, in all evaluated regions. These data provide strong evidence of the presence of the Leishmania parasite in the nervous milieu and contribute to a new perspective of the pathogenesis of visceral leishmaniasis. (C) 2014 Elsevier B.V. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionUniv Estadual Paulista, UNESP, Coll Vet Med, Lab Appl Pathol LApap, Aracatuba, SP, Brazil
dc.descriptionUniv Extremadura, Fac Vet, Parasitol Unit, LeishmanCeres Lab GLP Compliance Certified, Caceres, Spain
dc.descriptionUniv Estadual Paulista, UNESP, Coll Vet Med, Lab Appl Pathol LApap, Aracatuba, SP, Brazil
dc.descriptionFAPESP: 12/21129-9
dc.descriptionFAPESP: 11/03504-4
dc.descriptionFAPESP: 12/10415-0
dc.format376-380
dc.languageeng
dc.publisherElsevier B.V.
dc.relationVeterinary Parasitology
dc.relation2.422
dc.relation1,275
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectEncephalon
dc.subjectFFPE
dc.subjectParasite load
dc.subjectReal-time PCR
dc.subjectVisceral leishmaniasis
dc.titleFirst detection of Leishmania infantum DNA within the brain of naturally infected dogs
dc.typeArtigo


Este ítem pertenece a la siguiente institución