Sensitive flow-injection spectrophotometric analysis of bromopride

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorLima, Liliane Spazzapam [UNESP]
dc.creatorWeinert, Patricia Los [UNESP]
dc.creatorPezza, Leonardo [UNESP]
dc.creatorPezza, Helena Redigolo [UNESP]
dc.date2015-03-18T15:54:04Z
dc.date2015-03-18T15:54:04Z
dc.date2014-12-10
dc.date.accessioned2023-09-09T11:10:27Z
dc.date.available2023-09-09T11:10:27Z
dc.identifierhttp://dx.doi.org/10.1016/j.saa.2014.06.027
dc.identifierSpectrochimica Acta Part A-molecular And Biomolecular Spectroscopy. Oxford: Pergamon-elsevier Science Ltd, v. 133, p. 597-604, 2014.
dc.identifier1386-1425
dc.identifierhttp://hdl.handle.net/11449/116741
dc.identifier10.1016/j.saa.2014.06.027
dc.identifierWOS:000340330900077
dc.identifier5978908591853524
dc.identifier3192125098361121
dc.identifier0000-0003-0197-7369
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8766226
dc.descriptionA flow injection spectrophotometric procedure employing merging zones is proposed for direct bromopride determination in pharmaceutical formulations and biological fluids. The proposed method is based on the reaction between bromopride and p-dimethylaminocinnamaldehyde (p-DAC) in acid medium, in the presence of sodium dodecyl sulfate (SDS), resulting in formation of a violet product (lambda(max) = 565 nm). Experimental design methodologies were used to optimize the experimental conditions. The Beer-Lambert law was obeyed in a bromopride concentration range of 3.63 x 10(-7) to 2.90 x 10(-5) mol L-1, with a correlation coefficient (r) of 0.9999. The limits of detection and quantification were 1.07 x 10(-7) and 3.57 x 10(-7) mol L-1, respectively. The proposed method was successfully applied to the determination of bromopride in pharmaceuticals and human urine, and recoveries of the drug from these media were in the ranges 99.6-101.2% and 98.6-102.1%, respectively. This new flow injection procedure does not require any sample pretreatment steps. (C) 2014 Elsevier B.V. All rights reserved.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionUniv Estadual Paulista, UNESP, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.format597-604
dc.languageeng
dc.publisherElsevier B.V.
dc.relationSpectrochimica Acta Part A-molecular And Biomolecular Spectroscopy
dc.relation2.880
dc.relation0,648
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBromopride
dc.subjectFlow injection analysis
dc.subjectPharmaceuticals
dc.subjectUrine
dc.titleSensitive flow-injection spectrophotometric analysis of bromopride
dc.typeArtigo


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