Blood Profile and Histology in Oral Infections Associated with Diabetes

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade Estadual de Maringá (UEM)
dc.creatorCintra, Luciano Tavares Angelo [UNESP]
dc.creatorSilva Facundo, Aguinaldo Candido da [UNESP]
dc.creatorCarrara Prieto, Annelise Katrine [UNESP]
dc.creatorSumida, Doris Hissako [UNESP]
dc.creatorNarciso, Luis Gustavo [UNESP]
dc.creatorBomfim, Suely Regina Mogami [UNESP]
dc.creatorOliveira e Silva, Cleverson
dc.creatorDezan Júnior, Eloi [UNESP]
dc.creatorGomes-Filho, Joao Eduardo [UNESP]
dc.date2015-03-18T15:53:37Z
dc.date2015-03-18T15:53:37Z
dc.date2014-08-01
dc.date.accessioned2023-09-09T11:07:52Z
dc.date.available2023-09-09T11:07:52Z
dc.identifierhttp://dx.doi.org/10.1016/j.joen.2014.01.034
dc.identifierJournal Of Endodontics. New York: Elsevier Science Inc, v. 40, n. 8, p. 1139-1144, 2014.
dc.identifier0099-2399
dc.identifierhttp://hdl.handle.net/11449/116625
dc.identifier10.1016/j.joen.2014.01.034
dc.identifierWOS:000340686400016
dc.identifier9235743081667362
dc.identifier8275401688702343
dc.identifier8813777272581972
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8766110
dc.descriptionIntroduction: We aimed to investigate the relationship between blood profile and histologic findings in both apical periodontitis (AP) and periodontal disease (PD) associated with diabetes. Methods: Wistar rats (N = 80) were assigned to the following 8 groups: control, AP, PD, AP associated with PD, diabetes, diabetes with AP, diabetes with PD, and diabetes with AP and PD. Diabetes mellitus (DM) was induced with streptozotocin, AP was induced by exposure to the oral environment, and PD was induced using periodontal ligature. After 30 days, blood samples were collected, and the rats were euthanized. Subsequently, the maxillae were processed for light microscopy. Hematologic examinations were conducted to determine the total number of erythrocytes and leukocytes, erythrocyte constant, and blood glucose level. One-way analysis of variance and Kruskal-Wallis tests were used for statistical analysis, and the significance was set at P < .05. Results: A significant correlation was found between the histologic findings and blood parameters. Conclusions: In conclusion, diabetes accelerated the development and progression of AP and PD in the rats and caused an increase in the average erythrocyte volume as well as the leukocyte and neutrophil counts. Oral infections increase the total number of leukocytes, the number of neutrophils and lymphocytes, and blood glucose concentrations in DM rats.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionUniv Estadual Paulista, UNESP, Aracatuba Dent Sch, Dept Endodont, Sao Paulo, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, Aracatuba Dent Sch, Dept Basic Sci, Sao Paulo, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, Dept Clin & Surg & Anim Reprod, Sao Paulo, Brazil
dc.descriptionUEM Univ Estadual Maringa, Maringa Dent Sch, Dept Periodont, Maringa, Parana, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, Aracatuba Dent Sch, Dept Endodont, Sao Paulo, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, Aracatuba Dent Sch, Dept Basic Sci, Sao Paulo, Brazil
dc.descriptionUniv Estadual Paulista, UNESP, Dept Clin & Surg & Anim Reprod, Sao Paulo, Brazil
dc.descriptionFAPESP: 12/02083-8
dc.descriptionFAPESP: 12/04588-0
dc.descriptionFAPESP: 10/16999-9
dc.format1139-1144
dc.languageeng
dc.publisherElsevier B.V.
dc.relationJournal Of Endodontics
dc.relation2.886
dc.relation1,585
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectApical periodontitis
dc.subjectblood count
dc.subjectdiabetes
dc.subjectoral infections
dc.subjectperiodontal disease
dc.titleBlood Profile and Histology in Oral Infections Associated with Diabetes
dc.typeArtigo


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