PRESSER MECHANISMS IN ADRIAMYCIN-INDUCED NEPHROPATHY WITH HYPERTENSION IN RATS

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFranco, R.
dc.creatorGut, Ana Lúcia
dc.creatorFerrarispadotto, A.
dc.creatorGeorgette, J.
dc.creatorGAVRAS, I
dc.creatorGavras, H.
dc.date2014-05-20T15:21:02Z
dc.date2016-10-25T17:54:17Z
dc.date2014-05-20T15:21:02Z
dc.date2016-10-25T17:54:17Z
dc.date1994-01-01
dc.date.accessioned2017-04-05T23:29:00Z
dc.date.available2017-04-05T23:29:00Z
dc.identifierHypertension. Dallas: Amer Heart Assoc, v. 23, n. 1, p. I246-I249, 1994.
dc.identifier0194-911X
dc.identifierhttp://hdl.handle.net/11449/32227
dc.identifierhttp://acervodigital.unesp.br/handle/11449/32227
dc.identifier10.1161/01.HYP.23.1_Suppl.I246
dc.identifierWOS:A1994MR84300053
dc.identifierhttp://dx.doi.org/10.1161/01.HYP.23.1_Suppl.I246
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/876605
dc.descriptionWe explored the role of angiotensin II and vasopressin in the maintenance of blood pressure during the nephrotic syndrome of adriamycin-induced nephropathy in rats. All 91 rats treated with adriamycin developed chronic renal failure with nephrotic syndrome, which was more pronounced in the normotensive rats than the 35% who became hypertensive. Angiotensin II blockade with DuP 753 produced a significantly greater hypotensive response in both the adriamycin-hypertensive (-16+/-3 mmHg) and adriamycin-normotensive (-14+/-5 mmHg) groups than the saline-treated controls (-5+/-1 mm Hg, P<.05). Vasopressin blockade with either a V1V2 inhibitor or a selective V-1 inhibitor produced a hypotensive response in adriamycin-hypertensive rats only (by -16+/-4 and -17+/-2 mm Hg, respectively, P<.01), although the nonselective vasopressin inhibitor produced similar fluid loss and body weight reduction in all three groups. The data suggest that in adriamycin-induced nephropathy with nephrotic syndrome, angiotensin II contributes to blood pressure maintenance in both hypertensive and normotensive animals, whereas the presser action of vasopressin contributes to elevated blood pressure in hypertensive animals only.
dc.languageeng
dc.publisherAmer Heart Assoc
dc.relationHypertension
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDOXORUBICIN
dc.subjectRECEPTORS, VASOPRESSIN
dc.subjectANGIOTENSIN II
dc.subjectKIDNEY FAILURE
dc.titlePRESSER MECHANISMS IN ADRIAMYCIN-INDUCED NEPHROPATHY WITH HYPERTENSION IN RATS
dc.typeOtro


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