Screening and determination of sulphonamide residues in bovine milk samples using a flow injection system

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorBedatty Fernandes, Flavio Cesar [UNESP]
dc.creatorSilva, Aline Santana [UNESP]
dc.creatorRufino, Jose Luiz [UNESP]
dc.creatorPezza, Helena Redigolo [UNESP]
dc.creatorPezza, Leonardo [UNESP]
dc.date2015-03-18T15:53:30Z
dc.date2015-03-18T15:53:30Z
dc.date2015-01-01
dc.date.accessioned2023-09-09T11:06:36Z
dc.date.available2023-09-09T11:06:36Z
dc.identifierhttp://dx.doi.org/10.1016/j.foodchem.2014.06.034
dc.identifierFood Chemistry. Oxford: Elsevier Sci Ltd, v. 166, p. 309-315, 2015.
dc.identifier0308-8146
dc.identifierhttp://hdl.handle.net/11449/116551
dc.identifier10.1016/j.foodchem.2014.06.034
dc.identifierWOS:000342654200042
dc.identifier3192125098361121
dc.identifier5978908591853524
dc.identifier0000-0003-0197-7369
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8766036
dc.descriptionA new, simple, rapid and sensitive flow injection spectrophotometric method was developed for the screening and determination of sulphonamides in bovine milk samples. The method is based on the condensation of sulphathiazole, sulphamethazine, and sulphadimethoxine with p-dimethylaminobenzaldehyde (p-DAB) in acid medium, in the presence of sodium dodecyl sulphate (SDS), producing a yellow compound (lambda(max) = 465 nm). Optimisation of the experimental parameters was performed using a multivariate methodology. The linear range was 90-500 mu g/L and the limits of detection and quantification were in the ranges 25-29 mu g/L and 84-88 mu g/L, respectively. The procedure was applied for the determination of sulphonamide antibiotics in bovine milk samples submitted to a prior extraction procedure based on QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) methodology. Recoveries of 60.5-70.5% were achieved for milk samples spiked with 0.09, 0.1, 0.2, and 0.3 mu g/g of each sulphonamide. (C) 2014 Elsevier Ltd. All rights reserved.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.descriptionUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.format309-315
dc.languageeng
dc.publisherElsevier B.V.
dc.relationFood Chemistry
dc.relation4.946
dc.relation1,793
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSulphonamides
dc.subjectp-Dimethylaminobenzaldehyde
dc.subjectSpectrophotometry
dc.subjectScreening
dc.subjectFlow injection analysis
dc.subjectMilk
dc.titleScreening and determination of sulphonamide residues in bovine milk samples using a flow injection system
dc.typeArtigo


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