Telomere and Telomerase Biology

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorGiardini, Miriam Aparecida [UNESP]
dc.creatorSegatto, Marcela [UNESP]
dc.creatorSilva, Marcelo Santos da [UNESP]
dc.creatorNunes, Vinicius Santana [UNESP]
dc.creatorNogueira Cano, Maria Isabel [UNESP]
dc.creatorCalado, R. T.
dc.date2015-03-18T15:53:14Z
dc.date2015-03-18T15:53:14Z
dc.date2014-01-01
dc.date.accessioned2023-09-09T11:03:55Z
dc.date.available2023-09-09T11:03:55Z
dc.identifierhttp://dx.doi.org/10.1016/B978-0-12-397898-1.00001-3
dc.identifierTelomeres In Health And Disease. San Diego: Elsevier Academic Press Inc, v. 125, p. 1-40, 2014.
dc.identifier1877-1173
dc.identifierhttp://hdl.handle.net/11449/116389
dc.identifier10.1016/B978-0-12-397898-1.00001-3
dc.identifierWOS:000339223600002
dc.identifier7449821021440644
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8765874
dc.descriptionTelomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special structures that cap chromosome ends to prevent degradation by nucleolytic attack and to distinguish chromosome termini from DNA double-strand breaks. With few exceptions, telomeres are composed primarily of repetitive DNA associated with proteins that interact specifically with double- or single-stranded telomeric DNA or with each other, forming highly ordered and dynamic complexes involved in telomere maintenance and length regulation. In proliferative cells and unicellular organisms, telomeric DNA is replicated by the actions of telomerase, a specialized reverse transcriptase. In the absence of telomerase, some cells employ a recombination-based DNA replication pathway known as alternative lengthening of telomeres. However, mammalian somatic cells that naturally lack telomerase activity show telomere shortening with increasing age leading to cell cycle arrest and senescence. In another way, mutations or deletions of telomerase components can lead to inherited genetic disorders, and the depletion of telomeric proteins can elicit the action of distinct kinases-dependent DNA damage response, culminating in chromosomal abnormalities that are incompatible with life. In addition to the intricate network formed by the interrelationships among telomeric proteins, long noncoding RNAs that arise from subtelomeric regions, named telomeric repeat-containing RNA, are also implicated in telomerase regulation and telomere maintenance. The goal for the next years is to increase our knowledge about the mechanisms that regulate telomere homeostasis and the means by which their absence or defect can elicit telomere dysfunction, which generally results in gross genomic instability and genetic diseases.
dc.descriptionUniv Estadual Paulista, UNESP Botucatu, Inst Biociencias, Dept Genet, Sao Paulo, Brazil
dc.descriptionUniv Estadual Paulista, UNESP Botucatu, Inst Biociencias, Dept Genet, Sao Paulo, Brazil
dc.format1-40
dc.languageeng
dc.publisherElsevier B.V.
dc.relationTelomeres In Health And Disease
dc.relation3.074
dc.relation1,688
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.titleTelomere and Telomerase Biology
dc.typeArtigo


Este ítem pertenece a la siguiente institución