Modification of the brain proteome of Africanized honeybees (Apis mellifera) exposed to a subaEurolethal doses of the insecticide fipronil

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorUniversidade de São Paulo (USP)
dc.creatorRoat, T. C. [UNESP]
dc.creatorSantos-Pinto, J. R. A. dos [UNESP]
dc.creatorSantos, L. D. dos [UNESP]
dc.creatorSantos, K. S.
dc.creatorMalaspina, O. [UNESP]
dc.creatorPalma, M. S. [UNESP]
dc.date2015-03-18T15:53:02Z
dc.date2015-03-18T15:53:02Z
dc.date2014-11-01
dc.date.accessioned2023-09-09T11:02:31Z
dc.date.available2023-09-09T11:02:31Z
dc.identifierhttp://dx.doi.org/10.1007/s10646-014-1305-8
dc.identifierEcotoxicology. Dordrecht: Springer, v. 23, n. 9, p. 1659-1670, 2014.
dc.identifier0963-9292
dc.identifierhttp://hdl.handle.net/11449/116301
dc.identifier10.1007/s10646-014-1305-8
dc.identifierWOS:000343877400007
dc.identifier7538556085505819
dc.identifier2901888624506535
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8765788
dc.descriptionFipronil is a phenylpyrazole insecticide that is widely used in Brazilian agriculture for pest control. Although honeybees are not targets of fipronil, studies indicate that this pesticide can be harmful to honeybees. To assess the effects of fipronil in the brain of Africanized Apis mellifera workers, this study focused on the toxico-proteome profiling of the brain of newly emerged and aged honeybee workers that were exposed to a sub-lethal dose (10 pg fipronil per day. i.e. (1)/(100) of LD50/bee/day during 5 days) of the insecticide. Proteomic analysis identified 25 proteins that were differentially up-regulated or down-regulated when the fipronil-exposed and non-exposed groups were compared. These proteins are potentially related to pathogen susceptibility, neuronal chemical stress, neuronal protein misfolding, and occurrence of apoptosis, ischemia, visual impairment, damaged synapse formation, brain degeneration, memory and learning impairment. The exposure of honeybees to a very low dose of fipronil, even for a short period of time (5 days), was sufficient to cause a series of important neuroproteomic changes in the brains of honeybees.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionUniv Sao Paulo State UNESP, Ctr Study Social Insects, Dept Biol, Inst Biosci Rio Claro, Rio Claro, SP, Brazil
dc.descriptionUniv Sao Paulo State UNESP, Ctr Study Venoms & Venomous Anim CEVAP, Botucatu, SP, Brazil
dc.descriptionDiscipline Allergy & Immunol HC Incor FMUSP, Sao Paulo, Brazil
dc.descriptionUniv Sao Paulo State UNESP, Ctr Study Social Insects, Dept Biol, Inst Biosci Rio Claro, Rio Claro, SP, Brazil
dc.descriptionUniv Sao Paulo State UNESP, Ctr Study Venoms & Venomous Anim CEVAP, Botucatu, SP, Brazil
dc.descriptionFAPESP: 08/05018-7
dc.descriptionFAPESP: 12/13370-8
dc.descriptionFAPESP: 11/51684-1
dc.format1659-1670
dc.languageeng
dc.publisherSpringer
dc.relationEcotoxicology
dc.relation1.987
dc.relation0,797
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBrain proteome
dc.subjectPhenylpyrazole
dc.subjectInsecticide
dc.subjectProteomic analysis
dc.subject2-DE
dc.subjectMass spectrometry
dc.titleModification of the brain proteome of Africanized honeybees (Apis mellifera) exposed to a subaEurolethal doses of the insecticide fipronil
dc.typeArtigo


Este ítem pertenece a la siguiente institución