Streptococcal acute pharyngitis

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorAnjos, Lais Martins Moreira
dc.creatorMarcondes, Mariana Barros
dc.creatorLima, Mariana Ferreira
dc.creatorMondelli, Alessandro Lia [UNESP]
dc.creatorOkoshi, Marina Politi [UNESP]
dc.date2015-02-02T12:39:34Z
dc.date2015-02-02T12:39:34Z
dc.date2014-08-01
dc.date.accessioned2023-09-09T10:32:10Z
dc.date.available2023-09-09T10:32:10Z
dc.identifierhttp://dx.doi.org/10.1590/0037-8682-0265-2013
dc.identifierRevista da Sociedade Brasileira de Medicina Tropical. Sociedade Brasileira de Medicina Tropical - SBMT, v. 47, n. 4, p. 409-413, 2014.
dc.identifier0037-8682
dc.identifierhttp://hdl.handle.net/11449/114468
dc.identifier10.1590/0037-8682-0265-2013
dc.identifierS0037-86822014000400409
dc.identifierS0037-86822014000400409.pdf
dc.identifier4463138671998432
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8764023
dc.descriptionAcute pharyngitis/tonsillitis, which is characterized by inflammation of the posterior pharynx and tonsils, is a common disease. Several viruses and bacteria can cause acute pharyngitis; however, Streptococcus pyogenes (also known as Lancefield group A β-hemolytic streptococci) is the only agent that requires an etiologic diagnosis and specific treatment. S. pyogenes is of major clinical importance because it can trigger post-infection systemic complications, acute rheumatic fever, and post-streptococcal glomerulonephritis. Symptom onset in streptococcal infection is usually abrupt and includes intense sore throat, fever, chills, malaise, headache, tender enlarged anterior cervical lymph nodes, and pharyngeal or tonsillar exudate. Cough, coryza, conjunctivitis, and diarrhea are uncommon, and their presence suggests a viral cause. A diagnosis of pharyngitis is supported by the patient's history and by the physical examination. Throat culture is the gold standard for diagnosing streptococcus pharyngitis. However, it has been underused in public health services because of its low availability and because of the 1- to 2-day delay in obtaining results. Rapid antigen detection tests have been used to detect S. pyogenes directly from throat swabs within minutes. Clinical scoring systems have been developed to predict the risk of S. pyogenes infection. The most commonly used scoring system is the modified Centor score. Acute S. pyogenes pharyngitis is often a self-limiting disease. Penicillins are the first-choice treatment. For patients with penicillin allergy, cephalosporins can be an acceptable alternative, although primary hypersensitivity to cephalosporins can occur. Another drug option is the macrolides. Future perspectives to prevent streptococcal pharyngitis and post-infection systemic complications include the development of an anti-Streptococcus pyogenes vaccine.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionUniversidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de Clínica Médica
dc.descriptionUniversidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de Clínica Médica
dc.format409-413
dc.languageeng
dc.publisherSociedade Brasileira de Medicina Tropical - SBMT
dc.relationRevista da Sociedade Brasileira de Medicina Tropical
dc.relation1.358
dc.relation0,658
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subjectAcute rheumatic fever
dc.subjectAntigen
dc.subjectPenicillin
dc.subjectStreptococcal infection
dc.subjectTherapeutics
dc.titleStreptococcal acute pharyngitis
dc.typeArtigo


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