General anesthesia type does not influence serum levels of neutrophil gelatinase-associated lipocalin during the perioperative period in video laparoscopic bariatric surgery

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorSão Rafael Hospital Department of Surgery
dc.contributorSão Rafael Hospital Department of Anesthesiology
dc.creatorFernandes, Adriano
dc.creatorEttinger, João
dc.creatorAmaral, Fabiano
dc.creatorRamalho, Maria José
dc.creatorAlves, Rodrigo
dc.creatorMódolo, Norma Sueli Pinheiro [UNESP]
dc.date2015-02-02T12:39:33Z
dc.date2015-02-02T12:39:33Z
dc.date2014-12-01
dc.date.accessioned2023-09-09T10:32:07Z
dc.date.available2023-09-09T10:32:07Z
dc.identifierhttp://dx.doi.org/10.6061/clinics/2014(10)01
dc.identifierClinics. Faculdade de Medicina / USP, v. 69, n. 10, p. 655-659, 2014.
dc.identifier1807-5932
dc.identifierhttp://hdl.handle.net/11449/114465
dc.identifier10.6061/clinics/2014(10)01
dc.identifierS1807-59322014001000655
dc.identifierS1807-59322014001000655.pdf
dc.identifier8223546475724058
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8764020
dc.descriptionOBJECTIVES: Video laparoscopic bariatric surgery is the preferred surgical technique for treating morbid obesity. However, pneumoperitoneum can pose risks to the kidneys by causing a decrease in renal blood flow. Furthermore, as in other surgical procedures, laparoscopic bariatric surgery triggers an acute inflammatory response. Neutrophil gelatinase-associated lipocalin is an early and accurate biomarker of renal injury, as well as of the inflammatory response. Anesthetic drugs could offer some protection for the kidneys and could attenuate the acute inflammatory response from surgical trauma. The objective of this study was to compare the effects of two types of anesthetics, propofol and sevoflurane, on the serum levels of neutrophil gelatinase-associated lipocalin during the perioperative period in laparoscopic bariatric surgery. METHODS: Sixty-four patients scheduled for laparoscopic bariatric surgery were randomized into two anesthesia groups and were administered either total intravenous anesthesia (propofol) or inhalation anesthesia (sevoflurane). In the perioperative period, blood samples were collected at three time points (before anesthesia, 6 hours after pneumoperitoneum and 24 hours after pneumoperitoneum) and urine output was measured for 24 hours. Acute kidney injuries were evaluated by examining both the clinical and laboratory parameters during the postoperative period. The differences between the groups were compared using non-parametric tests. ReBEC (http://www.ensaiosclinicos.gov.br/rg/recruiting/): RBR-8wt2fy RESULTS: None of the patients developed an acute kidney injury during the study and no significant differences were found between the serum neutrophil gelatinase-associated lipocalin levels of the groups during the perioperative period. CONCLUSION: The choice of anesthetic drug, either propofol or sevoflurane, did not affect the serum levels of neutrophil gelatinase-associated lipocalin during the perioperative period in laparoscopic bariatric surgery.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionUniversidade Estadual Paulista (UNESP) Department of Botucatu Medical School Anesthesiology
dc.descriptionSão Rafael Hospital Department of Surgery
dc.descriptionSão Rafael Hospital Department of Anesthesiology
dc.descriptionUniversidade Estadual Paulista (UNESP) Department of Botucatu Medical School Anesthesiology
dc.format655-659
dc.languageeng
dc.publisherFaculdade de Medicina / USP
dc.relationClinics
dc.relation1.245
dc.relation0,536
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subjectMorbid Obesity
dc.subjectNGAL
dc.subjectBariatric Surgery
dc.subjectAcute Kidney Injury
dc.subjectAnesthesia
dc.titleGeneral anesthesia type does not influence serum levels of neutrophil gelatinase-associated lipocalin during the perioperative period in video laparoscopic bariatric surgery
dc.typeArtigo


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