Invasive head and neck cutaneous squamous cell carcinoma: clinical and histopathological characteristics, frequency of local recurrence and metastasis

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.creatorVasconcelos, Luiza [UNESP]
dc.creatorMelo, Juliana Carneiro [UNESP]
dc.creatorMiot, Hélio Amante [UNESP]
dc.creatorMarques, Mariângela Esther Alencar [UNESP]
dc.creatorAbbade, Luciana Patricia Fernandes [UNESP]
dc.date2015-02-02T12:39:25Z
dc.date2015-02-02T12:39:25Z
dc.date2014-07-01
dc.date.accessioned2023-09-09T10:29:23Z
dc.date.available2023-09-09T10:29:23Z
dc.identifierhttp://dx.doi.org/10.1590/abd1806-4841.20142810
dc.identifierAnais Brasileiros de Dermatologia. Sociedade Brasileira de Dermatologia, v. 89, n. 4, p. 562-568, 2014.
dc.identifier0365-0596
dc.identifierhttp://hdl.handle.net/11449/114299
dc.identifier10.1590/abd1806-4841.20142810
dc.identifierS0365-05962014000400562
dc.identifierS0365-05962014000400562.pdf
dc.identifier2543633050941005
dc.identifier8084974543029515
dc.identifier7528116925519142
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8763864
dc.descriptionBACKGROUND: squamous cell carcinoma is the second most common type of skin malignancy and may evolve to regional lymph node and distant metastases. OBJECTIVE: The objective of this study was to evaluate patients with head and neck cutaneous squamous cell carcinoma to identify its clinical and histopathological characteristics, as well as the frequency of local recurrence and metastasis. METHODS: A retrospective cohort of patients with head and neck cutaneous squamous cell carcinoma. Inclusion criteria: histopathological confirmation, follow-up for longer than one year after diagnosis. Exclusion criteria: immunosuppression; lip and oral cavity squamous cell carcinoma; and non-surgical resection of the lesion. We evaluated demographic, clinical and anatomopathologic findings and explored their associations. RESULTS: Sixty-one patients with 79 tumors and followed by 4.8±3.0 years were selected. The average age was 67.1 years, and 63% of tumors had up to two centimeters. Seven tumors (8.9%) recurred and two of them had positive margins. Recurrence was associated with higher Broders' grade (p<0.01). Two patients (3.3%) had regional lymph node metastases. There were no distant metastases. Seventy tumors were considered to be usual tumors (89.7%), and 68 (87.2%) were classified as Broders' grade 1 and 2. Additionally, 64.1% of tumors had a depth of invasion below four millimeters. Thirteen tumors (16.7%) had positive histological margins. CONCLUSIONS: Most patients had good prognosis in the first year of follow-up, confirming that head and neck cutaneous squamous cell carcinoma has a better prognosis than squamous cell carcinoma of other regions such as mucosa, oral cavity, and internal organs.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho
dc.descriptionUniversidade Estadual Paulista Júlio de Mesquita Filho
dc.format562-568
dc.languageeng
dc.publisherSociedade Brasileira de Dermatologia
dc.relationAnais Brasileiros de Dermatologia
dc.relation0.884
dc.relation0,520
dc.rightsAcesso aberto
dc.sourceSciELO
dc.subjectCarcinoma, squamous cell
dc.subjectLymphatic metastasis
dc.subjectNeoplasm recurrence, local
dc.subjectPathology
dc.subjectRecurrence
dc.titleInvasive head and neck cutaneous squamous cell carcinoma: clinical and histopathological characteristics, frequency of local recurrence and metastasis
dc.typeArtigo


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