A Critical Review of Properties of Darunavir and Analytical Methods for Its Determination

dc.contributorUniversidade Estadual Paulista (Unesp)
dc.contributorTrinity Coll Dublin
dc.contributorUniversidade de São Paulo (USP)
dc.creatorRuela Correa, Josilene Chaves [UNESP]
dc.creatorD'Arcy, Deirdre M.
dc.creatorReis Serra, Cristina Helena dos
dc.creatorSalgado, Hérida Regina Nunes [UNESP]
dc.date2014-12-03T13:11:44Z
dc.date2014-12-03T13:11:44Z
dc.date2014-01-02
dc.date.accessioned2023-09-09T10:16:14Z
dc.date.available2023-09-09T10:16:14Z
dc.identifierhttp://dx.doi.org/10.1080/10408347.2013.826573
dc.identifierCritical Reviews In Analytical Chemistry. Philadelphia: Taylor & Francis Inc, v. 44, n. 1, p. 16-22, 2014.
dc.identifier1040-8347
dc.identifierhttp://hdl.handle.net/11449/113474
dc.identifier10.1080/10408347.2013.826573
dc.identifierWOS:000326310900003
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8763071
dc.descriptionDarunavir is a synthetic non-peptidic protease inhibitor that has been shown to be extremely potent against wild-type HIV, and it is an important component of highly active antiretroviral treatment (HAART), which is considered as one of the most significant advances in the field of HIV therapy. However, there are some concerns about darunavir quality control. Darunavir shows pseudo-polymorphism: in different ambient conditions one pseudo-polymorphic form can change to another. This behavior of darunavir is problematic because the dosage form is exposed to different ambient conditions around the world, since HIV/AIDS is prevalent globally. Issues around differences in the solubility and effects that different forms of darunavir can cause are of concern, and a more stable form is preferable. Important investigations of darunavir such as dissolution behavior, polymorphism, stability and degradation studies, and the impact of that on the quality of the product are being conducted by our working group. A cure for HIV/AIDS remains a long-term commitment, and there is much yet to achieve. This article discusses, by a critical review of the literature, the impact of the use of darunavir in the treatment of HIV-infected patients, its physical-chemical properties, the analytical methods to determine it, and challenges that remain in order to ensure the quality and stability of darunavir.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.descriptionPADC-UNESP
dc.descriptionUniv Estadual Paulista, Sch Pharmaceut Sci, Drugs & Med Qual Control Lab, BR-14801902 Araraquara, SP, Brazil
dc.descriptionTrinity Coll Dublin, Sch Pharm & Pharmaceut Sci, Dublin, Ireland
dc.descriptionUniv Sao Paulo, Sch Pharmaceut Sci, Sao Paulo, Brazil
dc.descriptionUniv Estadual Paulista, Sch Pharmaceut Sci, Drugs & Med Qual Control Lab, BR-14801902 Araraquara, SP, Brazil
dc.format16-22
dc.languageeng
dc.publisherTaylor & Francis Inc
dc.relationCritical Reviews in Analytical Chemistry
dc.relation3.231
dc.relation0,819
dc.rightsAcesso restrito
dc.sourceWeb of Science
dc.subjectDarunavir
dc.subjectHPLC (high-performance
dc.subjectpressure liquid chromatography)
dc.subjectphysicochemical properties
dc.subjectquality control
dc.subjectstability
dc.titleA Critical Review of Properties of Darunavir and Analytical Methods for Its Determination
dc.typeResenha


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